Díaz-Ruiz Carmen, Parlato Rosanna, Aguado Fernando, Ureña Jesús M, Burgaya Ferran, Martínez Albert, Carmona Maria A, Kreiner Grzegorz, Bleckmann Susanne, Del Río Jose A, Schütz Günther, Soriano Eduardo
Institute for Research in Biomedicine-Barcelona (IRB), Department of Cell Biology and CIBERNED (ISCIII), University of Barcelona, Barcelona Science Park, Lab A1-S1, Josep Samitier 1-5, Barcelona 08028, Spain.
Mol Cell Neurosci. 2008 Dec;39(4):519-28. doi: 10.1016/j.mcn.2008.07.019. Epub 2008 Aug 5.
The family of CREB transcription factors is involved in a variety of biological processes including the development and plasticity of the nervous system. To gain further insight into the roles of CREB family members in the development of the embryonic brain, we examined the migratory phenotype of CREB1(Nescre)CREM(-/-) mutants. We found that the lack of CREB/CREM genes is accompanied by anatomical defects in specific layers of the olfactory bulb, hippocampus and cerebral cortex. These changes are associated with decreased Dab1 expression in CREB1(Nescre)CREM(-/-) mutants. Our results indicate that the lack of CREB/CREM genes, specifically in neural and glial progenitors, leads to migration abnormalities during brain development, suggesting that unidentified age-dependent factors modulate the role of CREB/CREM genes in neural development.
CREB转录因子家族参与多种生物学过程，包括神经系统的发育和可塑性。为了进一步深入了解CREB家族成员在胚胎大脑发育中的作用，我们研究了CREB1(Nescre)CREM(-/-)突变体的迁移表型。我们发现，CREB/CREM基因的缺失伴随着嗅球、海马体和大脑皮层特定层的解剖学缺陷。这些变化与CREB1(Nescre)CREM(-/-)突变体中Dab1表达的降低有关。我们的结果表明，CREB/CREM基因的缺失，特别是在神经和胶质祖细胞中，会导致大脑发育过程中的迁移异常，这表明未确定的年龄依赖性因素调节了CREB/CREM基因在神经发育中的作用。
Zotero 插件