Kofidis Theo, Gerd Paeschke Hans, Lichtenberg Artur, Emmert Maximilian, Woitek Felix, Didilis Vassilios, Haverich Axel, Klima Uwe
Department of Cardiac, Thoracic and Vascular Surgery, National University Hospital, National University of Singapore, Singapore.
Interact Cardiovasc Thorac Surg. 2009 Jan;8(1):49-53. doi: 10.1510/icvts.2008.185280. Epub 2008 Sep 11.
In the present study we identify parameters which influence the incidence of myocardial infarction (MI), need for percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and cardiac mortality after minimal invasive coronary artery bypass grafting (MIDCABG). With a mean follow-up of 30+/-11.2 months, 390 patients were assessed with Wald test-corrected chi(2) analysis to identify preoperative factors which correlate with a higher incidence of post-MIDCABG MI, PCI, CABG and mortality from cardiac causes. We found an increased incidence of postoperative MI in patients with 2-vessel (8.7%) and 3-vessel (7.7%) vs. 1.3% 1-vessel coronary artery disease (CAD) (P=0.023), and in patients with preceding cardiac procedure (CABG and PCI: 8.4% vs. 2.0% without, P=0.023). Also diabetes was associated with higher post-MIDCABG frequency of MI (P=0.035). Severity of angina was associated with lesser post-MIDCAB-PCI (P=0.011) while preceding CABG predicted a higher incidence (P=0.012). Preoperative low ejection fraction (EF) (multivariate, P<0.001), preoperative MI (P=0.007) and extent of CAD (P=0.001) were associated with a higher post-MIDCABG mortality. None of the parameters correlated with subsequent CABG MIDCABG. The extent and history of CAD, history of cardiac interventions and low EF seem to influence the outcome adversely and should be considered deciding pro or against the MIDCAB-option.
在本研究中,我们确定了影响心肌梗死(MI)发生率、经皮冠状动脉介入治疗(PCI)需求、冠状动脉旁路移植术(CABG)以及微创冠状动脉旁路移植术(MIDCABG)后心脏死亡率的参数。平均随访30±11.2个月,对390例患者进行了Wald检验校正的卡方分析,以确定与MIDCABG术后MI、PCI、CABG发生率及心源性死亡率较高相关的术前因素。我们发现,双支血管病变(8.7%)和三支血管病变(7.7%)患者术后MI的发生率高于单支血管冠状动脉疾病(CAD)患者(1.3%)(P = 0.023),有心脏手术史(CABG和PCI:8.4%对无手术史者的2.0%,P = 0.023)的患者也是如此。此外,糖尿病与MIDCABG术后较高的MI发生率相关(P = 0.035)。心绞痛严重程度与MIDCAB - PCI术后发生率较低相关(P = 0.011),而既往CABG则预示着较高的发生率(P = 0.012)。术前低射血分数(EF)(多因素分析,P < 0.001)、术前MI(P = 0.007)和CAD范围(P = 0.001)与MIDCABG术后较高的死亡率相关。没有参数与随后的CABG MIDCABG相关。CAD的范围和病史、心脏介入治疗史以及低EF似乎对结果有不利影响,在决定是否选择MIDCAB选项时应予以考虑。