Haddad L B, Laufer M R
Division of Gynecology, Department of Surgery, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
J Pediatr Adolesc Gynecol. 2008 Oct;21(5):243-6. doi: 10.1016/j.jpag.2007.09.004.
To determine if there is an association between pediatric ovarian malignancies and elevated platelet counts:
Retrospective chart review.
Large referral children's hospital.
154 patients taken to the operating room between February 1993 and February 2006 with an adnexal mass where ovarian tissue was submitted for pathological analysis.
The principle outcome was the presence of ovarian malignancy.
We found that there is an increase in thrombocytosis among individuals with ovarian malignancy, with as high as 33% of those with ovarian germ cell tumors demonstrating preoperative thrombocytosis.
These results suggest that thrombocytosis may be a useful marker for ovarian malignancy in this population. Further studies will be needed to determine if there is any prognostic value to thrombocytosis among these patients, with a potential value for counseling and future intervention based on these findings.
确定小儿卵巢恶性肿瘤与血小板计数升高之间是否存在关联。
回顾性病历审查。
大型转诊儿童医院。
1993年2月至2006年2月期间154例因附件肿块被送往手术室且提交卵巢组织进行病理分析的患者。
主要观察指标为卵巢恶性肿瘤的存在情况。
我们发现卵巢恶性肿瘤患者中血小板增多症有所增加，高达33%的卵巢生殖细胞肿瘤患者术前表现为血小板增多症。
这些结果表明血小板增多症可能是该人群卵巢恶性肿瘤的一个有用标志物。需要进一步研究以确定血小板增多症在这些患者中是否具有任何预后价值，以及基于这些发现进行咨询和未来干预的潜在价值。
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