静脉注射丙戊酸与苯妥英钠治疗癫痫持续状态和急性重复性癫痫发作的比较。
Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin.
作者信息
Gilad R, Izkovitz N, Dabby R, Rapoport A, Sadeh M, Weller B, Lampl Y
机构信息
Department of Neurology, Edith Wolfson Medical Center, Holon, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Acta Neurol Scand. 2008 Nov;118(5):296-300. doi: 10.1111/j.1600-0404.2008.01097.x.
OBJECTIVE
To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment.
MATERIALS AND METHODS
Patients with SE or ARS were treated in a consecutive manner with either VPA or PHT intravenously. The primary endpoint was defined as clinical seizure cessation; the secondary endpoint was evaluation of drug tolerability.
RESULTS
Seventy-four adult patients with SE or ARS participated in the study, 49 with VPA i.v. and 25 PHT i.v. In 43 (87.8%) of the VPA patients, the seizures discontinued, and no rescue medication was needed. Similar results were found in the PHT group in which seizures of 22 (88%) patients were well controlled. Side effects were found in 12% of the PHT group, and in none of the VPA group.
CONCLUSIONS
VPA i.v. seems to be effective and well tolerated in adult patients with SE or ARS.
目的
评估丙戊酸（VPA）治疗癫痫持续状态（SE）或急性重复性癫痫发作（ARS）患者的疗效和耐受性，并与苯妥英（PHT）治疗进行比较。
材料与方法
SE或ARS患者连续接受VPA或PHT静脉治疗。主要终点定义为临床癫痫发作停止；次要终点为药物耐受性评估。
结果
74例成年SE或ARS患者参与研究，49例接受VPA静脉注射，25例接受PHT静脉注射。43例（87.8%）VPA患者癫痫发作停止，无需急救药物。PHT组也有类似结果，22例（88%）患者的癫痫发作得到良好控制。PHT组12%的患者出现副作用，VPA组未出现副作用。
结论
静脉注射VPA对成年SE或ARS患者似乎有效且耐受性良好。
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