Kasch H, Qerama E, Kongsted A, Bendix T, Jensen T S, Bach F W
Danish Pain Research Center, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Eur J Neurol. 2008 Nov;15(11):1222-30. doi: 10.1111/j.1468-1331.2008.02301.x. Epub 2008 Sep 18.
Physical mechanisms are the possible factors involved in the development and maintenance of long-term handicaps after acute whiplash injury. This study prospectively examined the role of active neck mobility, cervical and extra-cervical pains, as well as non-painful complaints after a whiplash injury as predictors for subsequent handicap.
Consecutive acute whiplash patients (n = 688) were interviewed and examined by a study nurse after the median of 5 days after injury, and divided into a high- or a low-risk group by an algorithm based on pain intensity, number of non-painful complaints and active neck mobility [active cervical range of motion (CROM)]. All 458 high-risk patients and 230 low-risk patients received mailed questionnaires after 3, 6 and 12 months. Two examiners examined all high-risk patients (n = 458) and 41 consecutive low-risk patients at median 11, 109, 380 days after injury. The main outcome measures were: handicaps, severe headaches, neck pain and neck disability.
The relative risk for a 1-year disability increased by 3.5 with initial intense neck pain and headaches, by 4.6 times with reduced CROM and by four times with multiple non-painful complaints.
Reduced active neck mobility, immediate intense neck pain and headaches and the presence of multiple non-painful complaints are the important prognostic factors for a 1-year handicap after acute whiplash.
物理机制是急性挥鞭样损伤后长期功能障碍发生和维持的可能因素。本研究前瞻性地探讨了主动颈部活动度、颈部及颈部以外部位疼痛以及挥鞭样损伤后的非疼痛性主诉作为后续功能障碍预测指标的作用。
连续纳入急性挥鞭样损伤患者(n = 688),在损伤后5天(中位数)由研究护士进行访谈和检查,并根据疼痛强度、非疼痛性主诉数量和主动颈部活动度[主动颈椎活动范围(CROM)]通过算法将其分为高风险组或低风险组。所有458例高风险患者和230例低风险患者在3、6和12个月后收到邮寄的问卷。两名检查者在损伤后中位数11、109、380天对所有高风险患者(n = 458)和41例连续的低风险患者进行检查。主要结局指标为:功能障碍、严重头痛、颈部疼痛和颈部功能障碍。
初始颈部剧痛和头痛使1年致残的相对风险增加3.5倍,CROM降低使相对风险增加4.6倍,多项非疼痛性主诉使相对风险增加4倍。
主动颈部活动度降低、即刻颈部剧痛和头痛以及存在多项非疼痛性主诉是急性挥鞭样损伤后1年功能障碍的重要预后因素。