敌是友？将一种宿主防御蛋白转变为病原体的帮凶。

Friend or foe? Turning a host defense protein into a pathogen's accomplice.

作者信息

Shen Aimee, Bogyo Matthew

机构信息

Department of Pathology and Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.

出版信息

Chem Biol. 2008 Sep 22;15(9):879-80. doi: 10.1016/j.chembiol.2008.09.001.

DOI:10.1016/j.chembiol.2008.09.001

PMID:18804024

Abstract

Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus pyogenes hijacks normal cystatin C function to convert it into a cofactor that enhances proteolytic destruction of host-defense antibodies.

摘要

胱抑素是半胱氨酸蛋白酶抑制剂，处于抵御将蛋白酶作为毒力因子分泌的病原体的防御前线。在本期中，文森茨等人（2008年）揭示了化脓性链球菌的细菌蛋白酶IdeS如何劫持正常的胱抑素C功能，将其转化为一种辅助因子，增强对宿主防御抗体的蛋白水解破坏作用。