Kacerovska Denisa, Szepe Peter, Vanecek Tomas, Nemcova Jana, Michal Michal, Mukensnabl Petr, Kazakov Dmitry V
Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic.
Am J Dermatopathol. 2008 Oct;30(5):472-6. doi: 10.1097/DAD.0b013e31817fb37f.
The authors report a case of basaloid carcinoma involving the anus and rectum of a 57-year-old woman. Microscopically, the tumor showed unusual morphologic features strongly resembling a spiradenocylindroma because it consisted, in most parts, of basaloid cell nodules arranged in a jigsaw-puzzle fashion containing or surrounded by eosinophilic basal membrane material; in addition, there were intratumoral lymphocytes. The overlying squamous epithelium manifested dysplastic changes compatible with in situ squamous carcinoma that gradually became invasive and blended with basaloid cell islands; additionally, there were koilocytes in the squamous epithelium. A molecular biology study identified HPV-16 in the lesional tissue. Analysis of the CYLD gene did not prove any mutation.
作者报告了一例57岁女性肛门和直肠基底样癌的病例。显微镜下，肿瘤呈现出异常的形态特征，与汗腺螺旋腺瘤极为相似，因为其大部分区域由呈拼图状排列的基底样细胞结节组成，这些结节包含嗜酸性基底膜物质或被其包围；此外，肿瘤内还有淋巴细胞。覆盖其上的鳞状上皮表现出与原位鳞状癌相符的发育异常变化，这些变化逐渐发展为浸润性，并与基底样细胞岛融合；此外，鳞状上皮中存在空泡细胞。一项分子生物学研究在病变组织中鉴定出了人乳头瘤病毒16型（HPV-16）。CYLD基因分析未发现任何突变。
