编码外皮蛋白的基因的古老起源，外皮蛋白是表皮及相关上皮组织交联包膜的前体。
Ancient origin of the gene encoding involucrin, a precursor of the cross-linked envelope of epidermis and related epithelia.
作者信息
Vanhoutteghem Amandine, Djian Philippe, Green Howard
机构信息
Unité Propre de Recherche 2228 du Centre National de la Recherche Scientifique, Centre Universitaire des Saints-Pères, Université Paris Descartes, 45, rue des Saints-Pères, 75006 Paris, France.
出版信息
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15481-6. doi: 10.1073/pnas.0807643105. Epub 2008 Sep 22.
Abstract
The cross-linked (cornified) envelope is a characteristic product of terminal differentiation in the keratinocyte of the epidermis and related epithelia. This envelope contains many proteins of which involucrin was the first to be discovered and shown to become cross-linked by a cellular transglutaminase. Involucrin has evolved greatly in placental mammals, but retains the glutamine repeats that make it a good substrate for the transglutaminase. Until recently, it has been impossible to detect involucrin outside the placental mammals, but analysis of the GenBank and Ensembl databases that have become available since 2006 reveals the existence of involucrin in marsupials and birds. We describe here the properties of these involucrins and the ancient history of their evolution.
摘要
交联（角质化）包膜是表皮和相关上皮细胞角质形成细胞终末分化的特征性产物。该包膜包含多种蛋白质，其中包壳蛋白是最早被发现并被证明可被细胞转谷氨酰胺酶交联的。包壳蛋白在胎盘哺乳动物中发生了很大的进化，但保留了使其成为转谷氨酰胺酶良好底物的谷氨酰胺重复序列。直到最近，在胎盘哺乳动物之外还无法检测到包壳蛋白，但对2006年以来可用的GenBank和Ensembl数据库的分析揭示了有袋动物和鸟类中存在包壳蛋白。我们在此描述这些包壳蛋白的特性及其进化的古老历史。
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