伐地那非显著缓解老年糖尿病男性的勃起功能障碍

[Vardenafil significantly alleviates erectile dysfunction in aged men with diabetes].

作者信息

Zhang Zhong-Lin, Li Huo-Jin, Zhen Wan-Hua, Yuan Rong

机构信息

Department of Urology, Second People's Hospital of Shenzhen, Shenzhen, Guangdong 518035, China.

出版信息

Zhonghua Nan Ke Xue. 2008 Aug;14(8):737-9.

PMID:18817350

Abstract

OBJECTIVE

To observe the efficacy and safety of vardenafil in the treatment of erectile dysfunction (ED) in aged men with diabetes mellitus (DM).

METHODS

One hundred outpatients with diagnosed ED (40 diabetic and 60 non-diabetic) received vardenafil at the initial dose of 20 mg and sustained dose of 10 mg once a week for 8 weeks, and their erectile functions were evaluated by IIEF and EQS.

RESULTS

The scores on IIEF and EQS in the diabetic ED group were 18.9 +/- 0.2 and 25.1 +/- 1.4 after the vardenafil treatment, significantly higher than 8.1 +/- 0.5 and 9.1 +/- 1.3 before the treatment (P < 0.01), and the non-diabetic group scored 21.1 +/- 0.2 and 34.2 +/- 1.2 on IIEF and EQS after the treatment, as compared with the statistically lower scores of 10.1 +/- 0.3 and 10.1 +/- 1.7 before it (P < 0.01). The total rate of effectiveness was 65% in the diabetic and 73.30% in the non-diabetic group, with statistical differences (P < 0. 05).

CONCLUSION

Vardenafil can significantly improve erectile function and is well tolerated in the aged males with diabetic ED.

摘要

目的

观察伐地那非治疗老年糖尿病男性勃起功能障碍（ED）的疗效及安全性。

方法

100例确诊为ED的门诊患者（40例糖尿病患者和60例非糖尿病患者）初始剂量服用伐地那非20mg，维持剂量为每周1次10mg，共治疗8周，采用国际勃起功能指数（IIEF）和勃起功能问卷简表（EQS）评估其勃起功能。

结果

伐地那非治疗后，糖尿病ED组IIEF和EQS评分分别为18.9±0.2和25.1±1.4，显著高于治疗前的8.1±0.5和9.1±1.3（P<0.01）；非糖尿病组治疗后IIEF和EQS评分分别为21.1±0.2和34.2±1.2，显著高于治疗前的10.1±0.3和10.1±1.7（P<0.01）。糖尿病组总有效率为65%，非糖尿病组为73.30%，差异有统计学意义（P<0.05）。