Dore Gregory J, Haber Paul S
National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia.
Hepatology. 2008 Oct;48(4):1333-5. doi: 10.1002/hep.22595.
On January 2, 2008, the Nevada State Health Division (NSHD) contacted CDC concerning surveillance reports received by the Southern Nevada Health District (SNHD) regarding two persons recently diagnosed with acute hepatitis C. A third person with acute hepatitis C was reported the following day. This raised concerns about an outbreak because SNHD typically confirms four or fewer cases of acute hepatitis C per year. Initial inquiries found that all three persons with acute hepatitis C underwent procedures at the same endoscopy clinic (clinic A) within 35-90 days of illness onset. A joint investigation by SNHD, NSHD, and CDC was initiated on January 9, 2008. The epidemiologic and laboratory investigation revealed that hepatitis C virus (HCV) transmission likely resulted from reuse of syringes on individual patients and use of single-use medication vials on multiple patients at the clinic. Health officials advised clinic A to stop unsafe injection practices immediately, and approximately 40,000 patients of the clinic were notified about their potential risk for exposure to HCV and other bloodborne pathogens. This report focuses on the six cases of acute hepatitis C identified during the initial investigation, which is ongoing; additional cases of acute hepatitis C associated with exposures at clinic A might be identified. Comprehensive measures involving viral hepatitis surveillance, health-care provider education, public awareness, professional oversight, licensing, and improvements in medical devices can help detect and prevent transmission of HCV and other bloodborne pathogens in health-care settings.
2008年1月2日,内华达州卫生部门(NSHD)就南内华达卫生区(SNHD)收到的关于两名近期被诊断为急性丙型肝炎患者的监测报告,与美国疾病控制与预防中心(CDC)进行了联系。次日又报告了第三例急性丙型肝炎患者。这引发了对疫情爆发的担忧,因为SNHD通常每年确诊的急性丙型肝炎病例为4例或更少。初步调查发现,所有三名急性丙型肝炎患者在发病后35至90天内在同一家内镜诊所(诊所A)接受了诊疗。2008年1月9日,SNHD、NSHD和CDC展开了联合调查。流行病学和实验室调查显示,丙型肝炎病毒(HCV)传播可能是由于该诊所对个别患者重复使用注射器以及对多名患者使用一次性药瓶所致。卫生官员建议诊所A立即停止不安全的注射操作,并通知了该诊所约4万名患者他们可能面临感染HCV和其他血源性病原体的风险。本报告重点关注在初步调查期间发现的6例急性丙型肝炎病例,调查仍在进行中;可能还会发现与诊所A暴露相关的其他急性丙型肝炎病例。涉及病毒性肝炎监测、医护人员教育、公众意识、专业监督、许可及医疗器械改进等综合措施,有助于在医疗机构中检测和预防HCV及其他血源性病原体的传播。