(+)-莱帕定B的全合成：使用RC-ROM方法立体选择性合成非外消旋多取代对苯二酚

Total synthesis of (+)-lepadin B: stereoselective synthesis of nonracemic polysubstituted hydroquinolines using an RC-ROM process.

作者信息

Barbe Guillaume, Charette André B

机构信息

Département de chimie, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7.

出版信息

J Am Chem Soc. 2008 Oct 22;130(42):13873-5. doi: 10.1021/ja8068215. Epub 2008 Sep 27.

DOI:10.1021/ja8068215

PMID:18821760

Abstract

This communication describes a new tandem metathesis reaction for which an RC-ROM mechanism was experimentally supported. This process was successfully applied to the synthesis of cis-fused polyhydroquinolines enabling a short stereoselective total synthesis of ent-lepadin B.

摘要

本通讯描述了一种新的串联复分解反应，其RC-ROM机理得到了实验支持。该方法成功应用于顺式稠合多氢喹啉的合成，实现了对映体-勒帕定B的短程立体选择性全合成。