González-Aguilar A, Gutiérrez-Castrellón P, Briceño E, Rembao-Bojórquez D, Alonso-Vilatela M E, Rasmussen A
Departamento de Neurogenética y Biología Molecular, Instituto Nacional de Neurologíay Neurocirugía Manuel Velasco Suárez, México DF, México.
Rev Neurol. 2008;47(7):343-6.
Some previous studies have suggested familial aggregation of gliomas, although the results have not always been replicated.
In the present study of a Mexican population, we compared 100 cases of glioma with 124 healthy unrelated controls, as well as their 1st, 2nd and 3rd degree relatives (n = 3,575 and 4,520 respectively).
The relatives of the cases had a significantly higher risk of developing brain tumors than the relatives of controls (OR = 5.3; p < 0.05; 95% CI = 1.1-25.7), and their risk of developing any cancer was also increased (OR = 2; p < 0.05; 95% CI = 1.16-3.51), this risk was twofold for men when compared to females (OR = 2; p < 0.05; 95% CI = 1.15-3.37).
The present study supports familial aggregation of brain tumors and warrants further research into their genetic etiology.
Zotero 插件