Mahtab Mamun-Al, Rahman Salimur, Khan Mobin, Karim Fazal
Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Hepatobiliary Pancreat Dis Int. 2008 Oct;7(5):457-64.
Hepatitis B virus (HBV) infection is a major cause of mortality and morbidity globally. The quest continues to identify viral factors that influence disease progression and severity as well as responses to treatment of HBV infection. Based on variations in HBV, the virus has been divided into a number of genotypes.
Review of published literature on HBV genotypes.
HBV genotypes are likely to be important in determining the severity and progression of HBV-induced liver disease as well as responses to different anti-viral agents.
Although HBV genotyping is not yet recommended for routine use in treating HBV infection, available data suggest that, as in hepatitis C virus infection, HBV genotyping is also likely to become a routine investigation for HBV treatment, perhaps in the not too distant future.
乙型肝炎病毒（HBV）感染是全球范围内导致死亡和发病的主要原因。人们一直在寻找影响疾病进展和严重程度以及HBV感染治疗反应的病毒因素。根据HBV的变异情况，该病毒已被分为多个基因型。
对已发表的关于HBV基因型的文献进行综述。
HBV基因型可能在决定HBV所致肝病的严重程度和进展以及对不同抗病毒药物的反应方面具有重要意义。
虽然目前不建议在治疗HBV感染时常规进行HBV基因分型，但现有数据表明，与丙型肝炎病毒感染一样，HBV基因分型也可能在不久的将来成为HBV治疗的常规检查项目。
