Wasiak Jason, Cleland Heather, Campbell Fiona
Victorian Adult Burns Service, Alfred Hospital, Commercial Road , Prahran, Melbourne, Victoria, Australia, 3181.
Cochrane Database Syst Rev. 2008 Oct 8(4):CD002106. doi: 10.1002/14651858.CD002106.pub3.
An acute burn wound is a complex and evolving injury. Extensive burns produce, in addition to local tissue damage, systemic consequences. Treatment of partial thickness burn wounds is directed towards promoting healing, and a wide variety of dressings is currently available. Improvements in technology and advances in understanding of wound healing have driven the development of new dressings. Dressing selection should be based on their effects of healing, but ease of application and removal, dressing change requirements, cost and patient comfort should also be considered.
To assess the effects of burn wound dressings for superficial and partial thickness burns.
We searched the Cochrane Wounds Group Specialised Register (Searched 29/5/08); The Cochrane Central Register of Controlled Trials (CENTRAL) - The Cochrane Library Issue 2 2008; Ovid MEDLINE - 1950 to May Week 3 2008; Ovid EMBASE - 1980 to 2008 Week 21 and Ovid CINAHL - 1982 to May Week 4 2008.
All randomised controlled trials (RCTs) that evaluated the effects of burn wound dressings for superficial and partial thickness burns.
Two authors using standardised forms extracted the data independently. Each trial was assessed for internal validity with differences resolved by discussion.
A total of 26 RCTs are included in this review and most were methodologically poor. A number of dressings appear to have some benefit over other products in the management of superficial and partial thickness burns. This benefit relates to time to wound healing, the number of dressing changes and the level of pain experienced. The use of biosynthetic dressings is associated with a decrease in time to healing and reduction in pain during dressing changes. The use of silver sulphadiazine (SSD) as a comparator on burn wounds for the full duration of treatment needs to be reconsidered, as a number of studies showed delays in time to wound healing and increased number of dressing applications in patients treated with SSD dressings.
AUTHORS' CONCLUSIONS: There is a paucity of high quality RCTs on dressings for superficial and partial thickness burn injury. The studies summarised in this review evaluated a variety of interventions, comparators and clinical endpoints. Despite some potentially positive findings, the evidence, which largely derives from trials with methodological shortcomings, is of limited usefulness in aiding clinicians in choosing suitable treatments.
急性烧伤创面是一种复杂且不断演变的损伤。大面积烧伤除了造成局部组织损伤外,还会产生全身影响。浅Ⅱ度烧伤创面的治疗旨在促进愈合,目前有多种敷料可供选择。技术的进步和对伤口愈合认识的提高推动了新型敷料的研发。敷料的选择应基于其愈合效果,但也应考虑使用和去除的便捷性、换药要求、成本以及患者的舒适度。
评估烧伤创面敷料对浅Ⅱ度和深Ⅱ度烧伤的效果。
我们检索了Cochrane伤口小组专业注册库(检索日期为2008年5月29日);Cochrane对照试验中央注册库(CENTRAL)——Cochrane图书馆2008年第2期;Ovid MEDLINE——1950年至2008年第3周;Ovid EMBASE——1980年至2008年第21周以及Ovid CINAHL——1982年至2008年第4周。
所有评估烧伤创面敷料对浅Ⅱ度和深Ⅱ度烧伤效果的随机对照试验(RCT)。
两位作者使用标准化表格独立提取数据。对每个试验进行内部效度评估,如有分歧通过讨论解决。
本综述共纳入26项RCT,大多数在方法学上存在缺陷。在浅Ⅱ度和深Ⅱ度烧伤的处理中,一些敷料似乎比其他产品有一定优势。这种优势与伤口愈合时间、换药次数以及疼痛程度有关。使用生物合成敷料可缩短愈合时间并减轻换药时的疼痛。鉴于多项研究表明,使用磺胺嘧啶银(SSD)敷料治疗烧伤创面的患者伤口愈合时间延迟且换药次数增加,因此在整个治疗过程中将SSD用作对照需要重新考虑。
关于浅Ⅱ度和深Ⅱ度烧伤创面敷料的高质量RCT较少。本综述总结的研究评估了多种干预措施、对照和临床终点。尽管有一些潜在的阳性结果,但这些证据大多来自方法学有缺陷的试验,在帮助临床医生选择合适治疗方法方面的作用有限。