Zhou Xiu-ping, Cui Ling, Cui Yu-lin, Guo Hua-feng, Zhang Xi-min, Xu Guang-li
Child and Maternal Health Hospital, Zhengzhou, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2008 May;42(5):321-3.
To describe the prevalence trend and epidemiological characteristics of neural tube defects (NTDs) in perinatal in Zhengzhou city from 1996 to 2005.
Data collected from hospital were used to depict the epidemiology of NTDs in Zhengzhou. All perinatal fetuses born in hospitals had an access within 7 days after delivery. The prevalence were calculated by perinatal'year, sex, birth area (urban versus rural) and maternal age. All monitored perinatal (162,074) accounted for 32.66% from totals (496,203).
All 238 cases were found NTDs, and the overall prevalence rate was 14.68/10,000. The annual prevalence rate presented a decreasing trend during that period. The rates in rural and urban area, in male and female birth were 29.28/10,000 and 9.63/10,000, 11.42/10,000 and 17.74/10,000 respectively. There were significant differences among maternal-age-specific prevalence rates (chi2 = 22.952, P = 0.000). The rates of <20 years group(53.76/10,000) and >35 years group(21.74/10,000) were higher than others.
The prevalence rates of NTDs in rural area is higher than that in urban, female's is higher than male's in Zhengzhou. The annual prevalence rates of NTDs presents a decreasing trend in the past ten years.
描述1996年至2005年郑州市围产期神经管缺陷（NTDs）的流行趋势及流行病学特征。
采用医院收集的数据描述郑州市NTDs的流行病学情况。所有在医院出生的围产儿在出生后7天内进行登记。患病率按围产期年份、性别、出生地区（城市与农村）和母亲年龄进行计算。所有监测的围产儿（162,074例）占总数（496,203例）的32.66%。
共发现238例NTDs病例，总体患病率为14.68/万。在此期间，年患病率呈下降趋势。农村和城市地区的患病率分别为29.28/万和9.63/万，男婴和女婴的患病率分别为11.42/万和17.74/万。不同母亲年龄组的患病率存在显著差异（χ2 = 22.952，P = 0.000）。<20岁组（53.76/万）和>35岁组（21.74/万）的患病率高于其他组。
郑州市农村地区NTDs的患病率高于城市，女性高于男性。过去十年中，NTDs的年患病率呈下降趋势。
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