精神分裂症患者前额叶皮质和中脑中代谢型谷氨酸受体2和3的基因表达
Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.
作者信息
Ghose Subroto, Crook Jeremy M, Bartus Cynthia L, Sherman Thomas G, Herman Mary M, Hyde Thomas M, Kleinman Joel E, Akil Mayada
机构信息
Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA.
出版信息
Int J Neurosci. 2008 Nov;118(11):1609-27. doi: 10.1080/00207450802330702.
Abstract
Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in schizophrenia. We characterized mGluR2 and 3 mRNA in the human prefrontal cortex (PFC) and mesencephalon, and then compared cases with schizophrenia to matched controls. In the human brain, both receptors were expressed in the PFC and, unlike the rodent, in dopaminergic (DA) cell groups. In schizophrenia, we found significantly higher levels of mGluR2 mRNA in the PFC white matter. The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia.
摘要
第二组代谢型谷氨酸受体（mGluR2和mGluR3）与精神分裂症有关。我们对人类前额叶皮质（PFC）和中脑的mGluR2和3 mRNA进行了表征，然后将精神分裂症患者与匹配的对照组进行比较。在人脑中，这两种受体都在前额叶皮质中表达，与啮齿动物不同的是，在多巴胺能（DA）细胞群中也有表达。在精神分裂症患者中，我们发现前额叶皮质白质中mGluR2 mRNA水平显著升高。mGluR2、3在多巴胺能细胞中的表达为谷氨酸调节人脑中多巴胺释放提供了一种机制，这种物种特异性差异可能对理解精神分裂症的啮齿动物模型至关重要。
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