精神分裂症患者前额叶皮质和中脑中代谢型谷氨酸受体2和3的基因表达
Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.
作者信息
Ghose Subroto, Crook Jeremy M, Bartus Cynthia L, Sherman Thomas G, Herman Mary M, Hyde Thomas M, Kleinman Joel E, Akil Mayada
机构信息
Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, Maryland, USA.
出版信息
Int J Neurosci. 2008 Nov;118(11):1609-27. doi: 10.1080/00207450802330702.
Abstract
Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in schizophrenia. We characterized mGluR2 and 3 mRNA in the human prefrontal cortex (PFC) and mesencephalon, and then compared cases with schizophrenia to matched controls. In the human brain, both receptors were expressed in the PFC and, unlike the rodent, in dopaminergic (DA) cell groups. In schizophrenia, we found significantly higher levels of mGluR2 mRNA in the PFC white matter. The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia.
摘要
第二组代谢型谷氨酸受体（mGluR2和mGluR3）与精神分裂症有关。我们对人类前额叶皮质（PFC）和中脑的mGluR2和3 mRNA进行了表征，然后将精神分裂症患者与匹配的对照组进行比较。在人脑中，这两种受体都在前额叶皮质中表达，与啮齿动物不同的是，在多巴胺能（DA）细胞群中也有表达。在精神分裂症患者中，我们发现前额叶皮质白质中mGluR2 mRNA水平显著升高。mGluR2、3在多巴胺能细胞中的表达为谷氨酸调节人脑中多巴胺释放提供了一种机制，这种物种特异性差异可能对理解精神分裂症的啮齿动物模型至关重要。
相似文献
1
Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.
Int J Neurosci. 2008 Nov;118(11):1609-27. doi: 10.1080/00207450802330702.
2
Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia.
Synapse. 2005 Sep 1;57(3):123-31. doi: 10.1002/syn.20164.
3
Enhanced glutamatergic phenotype of mesencephalic dopamine neurons after neonatal 6-hydroxydopamine lesion.
Neuroscience. 2008 Sep 22;156(1):59-70. doi: 10.1016/j.neuroscience.2008.07.032. Epub 2008 Jul 25.
4
Repeated exposure to cocaine alters the modulation of mesocorticolimbic glutamate transmission by medial prefrontal cortex Group II metabotropic glutamate receptors.
J Neurochem. 2008 Oct;107(1):186-96. doi: 10.1111/j.1471-4159.2008.05593.x. Epub 2008 Jul 31.
5
Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice.
J Neurochem. 2006 Jun;97(5):1243-58. doi: 10.1111/j.1471-4159.2006.03754.x. Epub 2006 Mar 8.
6
ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia.
Neurobiol Dis. 2003 Dec;14(3):637-47. doi: 10.1016/j.nbd.2003.09.001.
7
Dopaminergic control of working memory and its relevance to schizophrenia: a circuit dynamics perspective.
Neuroscience. 2006 Apr 28;139(1):153-71. doi: 10.1016/j.neuroscience.2005.08.070. Epub 2005 Dec 1.
8
Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia.
Schizophr Res. 2019 Jun;208:353-359. doi: 10.1016/j.schres.2019.01.023. Epub 2019 Jan 31.
9
Prefrontal and Striatal Glutamate Differently Relate to Striatal Dopamine: Potential Regulatory Mechanisms of Striatal Presynaptic Dopamine Function?
J Neurosci. 2015 Jul 1;35(26):9615-21. doi: 10.1523/JNEUROSCI.0329-15.2015.
10
The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats.
Neuroscience. 2007 Mar 16;145(2):611-20. doi: 10.1016/j.neuroscience.2006.12.006. Epub 2007 Jan 16.
引用本文的文献
1
Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia.
Genes (Basel). 2023 Jan 18;14(2):243. doi: 10.3390/genes14020243.
2
White Matter Neurometabolic Signatures Support the Deficit and Nondeficit Distinction in Antipsychotic-Naïve First-Episode Psychosis Patients.
Schizophr Bull. 2021 Jul 8;47(4):1068-1076. doi: 10.1093/schbul/sbab014.
3
Regulation of Glutamatergic Activity via Bidirectional Activation of Two Select Receptors as a Novel Approach in Antipsychotic Drug Discovery.
Int J Mol Sci. 2020 Nov 20;21(22):8811. doi: 10.3390/ijms21228811.
4
Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors.
Cell Rep. 2020 May 5;31(5):107605. doi: 10.1016/j.celrep.2020.107605.
5
Chronic methamphetamine self-administration dysregulates 5-HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK-801.
Pharmacol Biochem Behav. 2018 Dec;175:89-100. doi: 10.1016/j.pbb.2018.09.007. Epub 2018 Sep 18.
6
Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic Drugs.
Front Pharmacol. 2016 May 20;7:130. doi: 10.3389/fphar.2016.00130. eCollection 2016.
7
Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment.
Trends Neurosci. 2015 Aug;38(8):506-16. doi: 10.1016/j.tins.2015.06.002. Epub 2015 Jul 4.
8
Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.
Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1196-201. doi: 10.1073/pnas.1416196112. Epub 2015 Jan 12.
9
Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.
Neuropharmacology. 2015 Mar;90:33-41. doi: 10.1016/j.neuropharm.2014.10.017. Epub 2014 Nov 1.
10
The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.
Ann N Y Acad Sci. 2015 Mar;1338(1):38-57. doi: 10.1111/nyas.12547. Epub 2014 Oct 14.
本文引用的文献
1
Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.
Schizophr Res. 2008 Jan;98(1-3):129-38. doi: 10.1016/j.schres.2007.09.032. Epub 2007 Oct 26.
2
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial.
Nat Med. 2007 Sep;13(9):1102-7. doi: 10.1038/nm1632. Epub 2007 Sep 2.
3
Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia.
Int J Neuropsychopharmacol. 2007 Aug;10(4):565-73. doi: 10.1017/S1461145706007310. Epub 2007 Feb 12.
4
Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia.
Ann Gen Psychiatry. 2006 Nov 28;5:19. doi: 10.1186/1744-859X-5-19.
5
Evidence for white matter abnormalities in schizophrenia.
Curr Opin Psychiatry. 2005 Mar;18(2):121-34. doi: 10.1097/00001504-200503000-00004.
6
Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex.
Am J Psychiatry. 2006 Apr;163(4):740-2. doi: 10.1176/ajp.2006.163.4.740.
7
Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia.
Neurosci Biobehav Rev. 2006;30(7):918-48. doi: 10.1016/j.neubiorev.2006.02.001. Epub 2006 Mar 31.
8
Alternative splicing of human metabotropic glutamate receptor 3.
J Neurochem. 2006 Feb;96(4):1139-48. doi: 10.1111/j.1471-4159.2005.03609.x. Epub 2006 Jan 17.
9
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia.
Nature. 2005 Dec 22;438(7071):1162-6. doi: 10.1038/nature04302.
10
Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia.
Synapse. 2005 Sep 1;57(3):123-31. doi: 10.1002/syn.20164.
Zotero 插件