Ritter J, Baldauf J J, Philippe E, Dreyfus M, Dillmann J C
Service de Gynécologie-Obstétrique I, Hôpital de Hautepierre, CHRU Strasbourg.
J Gynecol Obstet Biol Reprod (Paris). 1991;20(4):511-8.
A detailed colposcopy study of the cervix, vagina and vulva was conducted in 365 women referred for genital human papillomavirus (HPV) lesions, abnormal cervico-vaginal smear or cervical intraepithelial neoplasia (CIN). Valvuloscopic abnormalities, all biopsied, were found in 144 women, i.e. 40% of the population studied. Five types of vulvoscopic abnormalities are described: diffuse acidophilia (55% of abnormalities), acidophilic maculae (17%), micropapillae (20%), papulae (4%) and leucoparakeratosis (4%). Histological examination of the biopsy specimens obtained from 144 women with abnormal vulvoscopy showed 55 typical flat condylomas (38%), 50 probable flat condylomas (35%) and no signs of condyloma in 38 cases (27%). It also revealed the presence of four vulvar intraepithelial neoplasias (VIN) stages 2-3, all of them associated with typical or probable condyloma. Comparison between the 144 abnormal vulvoscopies and a series of 14 normal vulvoscopies made it possible to establish a significant correlation between the presence of valvuloscopic abnormalities and the finding of histological signs of typical or probable flat condyloma. The vulvoscopic images of subclinical vulvar HPV infection, but apart from papulae and, to a lesser extent, leucoparakeratosis, correlations between vulvoscopic and histological images were imprecise.
对365名因生殖器人乳头瘤病毒(HPV)病变、宫颈阴道涂片异常或宫颈上皮内瘤变(CIN)而转诊的女性进行了宫颈、阴道和外阴的详细阴道镜检查。在144名女性中发现了外阴镜异常,均进行了活检,占所研究人群的40%。描述了五种外阴镜异常类型:弥漫性嗜酸细胞增多(占异常的55%)、嗜酸细胞斑(17%)、微乳头(20%)、丘疹(4%)和白色角化病(4%)。对144名外阴镜检查异常的女性获取的活检标本进行组织学检查,结果显示55例典型扁平湿疣(38%)、50例可能的扁平湿疣(35%),38例(27%)未发现湿疣迹象。还发现了4例2 - 3级外阴上皮内瘤变(VIN),均与典型或可能的湿疣相关。通过对144例异常外阴镜检查结果与14例正常外阴镜检查结果进行比较,得以确定外阴镜异常的存在与典型或可能的扁平湿疣组织学征象的发现之间存在显著相关性。亚临床外阴HPV感染的外阴镜图像,但除丘疹以及程度较轻的白色角化病外,外阴镜图像与组织学图像之间的相关性并不精确。