Herzig T C, Buchholz R A, Haywood J R
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
Am J Physiol. 1991 Sep;261(3 Pt 2):H860-7. doi: 10.1152/ajpheart.1991.261.3.H860.
The contribution of the paraventricular nucleus region of the hypothalamus (PVN) to the maintenance of one-kidney, figure-8 renal wrap hypertension was determined in this study. Electrolytic ablation of the PVN was performed 4 wk after the production of hypertension or sham operation. Ablation of the PVN region significantly reduced mean arterial pressure (MAP) from 150 +/- 9 to 110 +/- 3 mmHg in the hypertensive rats. In the sham-hypertensive group, the lesion decreased MAP from 118 +/- 2 to 99 +/- 4 mmHg. In both groups of animals MAP from 118 +/- 2 to 99 +/- 4 mmHg. In both groups of animals MAP returned to prelesion values by day 7 postlesion. When ganglionic blockade was performed on day 7 postlesion, the fall in MAP was greater in hypertensive rats (-44 +/- 5 mmHg) than in normotensive rats (-26 +/- 3 mmHg). In a separate group of rats studied 3 days after PVN ablation, ganglionic blockade produced similar decreases in MAP in the wrapped and sham-operated animals. These studies suggest that the PVN contributes to the increased functional sympathetic nervous system associated with one-kidney, figure-8 renal hypertension. Although ablation of the PVN region decreases MAP, neural mechanisms compensate to return MAP to hypertensive levels.
本研究确定了下丘脑室旁核区域（PVN）对一侧肾脏“8”字形肾包膜高血压维持的作用。在高血压形成或假手术后4周进行PVN的电解毁损。PVN区域的毁损使高血压大鼠的平均动脉压（MAP）从150±9 mmHg显著降至110±3 mmHg。在假高血压组中，该损伤使MAP从118±2 mmHg降至99±4 mmHg。在两组动物中，MAP在损伤后第7天恢复到损伤前值。在损伤后第7天进行神经节阻断时，高血压大鼠的MAP下降幅度（-44±5 mmHg）大于正常血压大鼠（-26±3 mmHg）。在另一组PVN毁损后3天研究的大鼠中，神经节阻断使包绕肾脏和假手术动物的MAP产生相似程度的下降。这些研究表明，PVN促成了与一侧肾脏“8”字形肾高血压相关的功能性交感神经系统的增强。尽管PVN区域的毁损降低了MAP，但神经机制会进行代偿以使MAP恢复到高血压水平。
