Beers M H, Ouslander J G, Rollingher I, Reuben D B, Brooks J, Beck J C
Department of Medicine, UCLA Center for Health Sciences.
Arch Intern Med. 1991 Sep;151(9):1825-32.
Increasing attention is being paid to inappropriate medication use in nursing homes. However, criteria defining the appropriate or inappropriate use of medication in this setting are not readily available and are not uniform. We used a two-round survey, based on Delphi methods, with 13 nationally recognized experts to reach consensus on explicit criteria defining the inappropriate use of medications in a nursing home population. The criteria were designed to use pharmacy data with minimal additional clinical data so that they could be applied to chart review or computerized data sets. The 30 factors agreed on by this method identify inappropriate use of such commonly used categories of medications as sedative-hypnotics, antidepressants, antipsychotics, antihypertensives, nonsteroidal anti-inflammatory agents, oral hypoglycemics, analgesics, dementia treatments, platelet inhibitors, histamine2 blockers, antibiotics, decongestants, iron supplements, muscle relaxants, gastrointestinal antispasmodics, and antiemetics. These criteria may be useful for quality assurance review, health services research, and clinical practice guidelines. The method used to establish these criteria can be used to update and expand the guidelines in the future.
疗养院中不适当用药问题正日益受到关注。然而,界定该环境下药物使用适当与否的标准并不容易获取且不统一。我们基于德尔菲法进行了两轮调查,邀请了13位全国知名专家,就明确界定疗养院人群药物不当使用的标准达成共识。这些标准旨在利用药房数据并尽量减少额外的临床数据,以便应用于病历审查或计算机数据集。通过该方法达成一致的30个因素可识别镇静催眠药、抗抑郁药、抗精神病药、抗高血压药、非甾体抗炎药、口服降糖药、镇痛药、痴呆症治疗药物、血小板抑制剂、组胺2受体阻滞剂、抗生素、减充血剂、铁补充剂、肌肉松弛剂、胃肠道解痉药和止吐药等常用药物类别的不当使用情况。这些标准可能对质量保证审查、卫生服务研究和临床实践指南有用。用于建立这些标准的方法未来可用于更新和扩展指南。