对强小鼠乳腺肿瘤病毒超级抗原产生反应的BALB/Mtv基因敲除小鼠可限制乳腺肿瘤发生。
BALB/Mtv-null mice responding to strong mouse mammary tumor virus superantigens restrict mammary tumorigenesis.
作者信息
Bhadra Sanchita, Lozano Mary M, Dudley Jaquelin P
机构信息
Section of Molecular Genetics and Microbiology, The University of Texas at Austin, One University Station, A5000, 2506 Speedway, NMS 2.104, Austin, TX 78712-0162, USA.
出版信息
J Virol. 2009 Jan;83(1):484-8. doi: 10.1128/JVI.01374-08. Epub 2008 Oct 15.
The absence of endogenous mouse mammary tumor viruses (MMTVs) in the congenic mouse strain, BALB/Mtv-null, restricts the early steps of exogenous C3H MMTV infection, preventing the superantigen (Sag) response and mammary tumorigenesis. Here we demonstrate that BALB/Mtv-null mice also resist tumor induction by FM MMTV, which encodes a stronger Sag compared to C3H MMTV. In contrast to infections with C3H MMTV, Mtv-null mice show FM-MMTV Sag-specific responses comparable to those observed in susceptible BALB/c mice. Neither virus shows significant replication in the spleen or mammary gland. Thus, Mtv-null mice restrict MMTV replication and mammary tumorigenesis even after a robust Sag response.
同源近交系小鼠BALB/Mtv-null中缺乏内源性小鼠乳腺肿瘤病毒（MMTV），这限制了外源性C3H MMTV感染的早期步骤，阻止了超抗原（Sag）反应和乳腺肿瘤发生。在此，我们证明BALB/Mtv-null小鼠也能抵抗FM MMTV诱导的肿瘤，与C3H MMTV相比，FM MMTV编码更强的Sag。与C3H MMTV感染不同，Mtv-null小鼠表现出与易感的BALB/c小鼠中观察到的类似的FM-MMTV Sag特异性反应。两种病毒在脾脏或乳腺中均未显示出显著复制。因此，即使在强烈的Sag反应后，Mtv-null小鼠仍能限制MMTV复制和乳腺肿瘤发生。
Zotero 插件