ter Meulen Ph H, Berghmans L C M, Nieman F H M, van Kerrebroeck Ph E V A
Department of Urology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.
Int Urogynecol J Pelvic Floor Dysfunct. 2009 Feb;20(2):177-83. doi: 10.1007/s00192-008-0741-5. Epub 2008 Oct 21.
A study was carried out to evaluate efficacy of Macroplastique(R) (MPQ) Implantation System (MIS) in women with urodynamic stress urinary incontinence (SUI) and urethral hypermobility after an unsuccessful conservative treatment. This is a prospective randomized controlled trial in women without previous incontinence surgery. Twenty-four women received MPQ. Twenty-one controls underwent a pelvic floor muscle exercises home program. Follow-up was at 3 months and the MPQ group also at 12 months. At 3 months, pad usage decreased significantly more in the MPQ group than in the control group (p = 0.015). According to physician and patient self-assessment, respectively, 71% and 63% women in the MPQ group were considered cured or markedly improved. This was significantly higher compared to controls. There was a significant higher increase of Incontinence Quality-of-Life questionnaire score in the MPQ group compared to controls (p = 0.017). Improvements in MPQ group at 3 months are sustained to 12 months. Adverse events were mild and transient. MIS is an acceptable option for women with SUI and urethral hypermobility.
一项研究旨在评估Macroplastique®（MPQ）植入系统（MIS）对保守治疗失败后患有尿动力学压力性尿失禁（SUI）和尿道活动过度的女性的疗效。这是一项针对未接受过失禁手术的女性的前瞻性随机对照试验。24名女性接受了MPQ治疗。21名对照组女性进行了家庭盆底肌肉锻炼计划。随访时间为3个月，MPQ组还进行了12个月的随访。在3个月时，MPQ组的护垫使用量减少幅度明显大于对照组（p = 0.015）。根据医生和患者的自我评估，MPQ组分别有71%和63%的女性被认为治愈或明显改善。与对照组相比，这一比例明显更高。与对照组相比，MPQ组的尿失禁生活质量问卷评分显著提高（p = 0.017）。MPQ组在3个月时的改善持续到12个月。不良事件轻微且短暂。MIS是患有SUI和尿道活动过度的女性的一个可接受的选择。
