大鼠骨骼肌中的蛋白激酶C活性。与体重和肌肉生长的明显关系。

Protein kinase C activity in rat skeletal muscle. Apparent relation to body weight and muscle growth.

作者信息

Richter E A, Nielsen N B

机构信息

August Krogh Institute, University of Copenhagen, Denmark.

出版信息

FEBS Lett. 1991 Sep 2;289(1):83-5. doi: 10.1016/0014-5793(91)80913-n.

DOI:10.1016/0014-5793(91)80913-n

PMID:1894010

Abstract

Protein kinase C (PKC) may be involved in growth regulation. In the present study the relationship between body weight, and thereby age, and the activity of PKC in muscle as well as in rapidly growing overloaded muscle were investigated. PKC activity in music was linearly inversely correlated to rat weight in both soleus (r = -0.59, P less than 0.05) and in plantaris (r = -0.74, P less than 0.01) muscles. During compensatory hypertrophy. PKC activity per muscle was maximally increased compared with the contralateral control muscles after 4 days in both soleus (126%) and in plantaris (105%) but had returned to basal levels by the 9th day. The data are in agreement with a role for PKC in muscle growth.

摘要

蛋白激酶C（PKC）可能参与生长调节。在本研究中，研究了体重以及由此而来的年龄与肌肉中PKC活性之间的关系，以及在快速生长的超负荷肌肉中PKC的活性。在比目鱼肌（r = -0.59，P < 0.05）和跖肌（r = -0.74，P < 0.01）中，肌肉中的PKC活性与大鼠体重呈线性负相关。在代偿性肥大过程中，比目鱼肌和跖肌在4天后，每块肌肉的PKC活性与对侧对照肌肉相比最大增加（比目鱼肌增加126%，跖肌增加105%），但在第9天已恢复到基础水平。这些数据与PKC在肌肉生长中的作用一致。