[丙戊酸钠、芬那西泮和生育酚对大鼠应激性肝损伤保护作用的比较评估]
[Comparative evaluation of the protective effect of sodium valproate, phenazepam and ionol in stress-induced liver damage in rats].
作者信息
Nikonorov A A, Tverdokhlib V P
出版信息
Fiziol Zh (1978). 1991 May-Jun;37(3):66-70.
PMID:1894054
Abstract
Ionol, a synthetic antioxidant, limits the stressor liver injury to a greater extent than sodium, valproate and phenazepam, activators of a GABA-ergic link of the stress-limiting organism systems. This injury is exhibited in the organospecific elevated levels of blood enzymes fructosediphosphate aldolase depression of N-demethylase activity of microsomal monooxygenases and a decrease in the amount of cytochromes P-450 and B5.
摘要
离子醇，一种合成抗氧化剂，比应激限制机体系统的γ-氨基丁酸能环节激活剂（如丙戊酸钠和非那西泮）更能在更大程度上限制应激源对肝脏的损伤。这种损伤表现为器官特异性的血液酶（果糖二磷酸醛缩酶）水平升高、微粒体单加氧酶N-脱甲基酶活性降低以及细胞色素P-450和B5含量减少。
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