Veyrac Alexandra, Sacquet Joëlle, Nguyen Véronique, Marien Marc, Jourdan François, Didier Anne
Université de Lyon, Lyon F-69007, Université Lyon 1, F-69007, Lyon, France.
Neuropsychopharmacology. 2009 Feb;34(3):786-95. doi: 10.1038/npp.2008.191. Epub 2008 Oct 22.
Commonly used experimental paradigms of environmental enrichment combine increased social interactions and sensory inputs and renewal of the objects present in the environment. However, the specific contribution of novelty to the effects of enrichment is unclear. Here, we show that repeated daily exposure to single novel odorants and not to an enriched but stable olfactory environment improves short-term olfactory memory and neurogenesis in the mouse olfactory bulb. In addition, these positive effects are mediated by noradrenalin as they are blocked by a noradrenergic receptor antagonist. These data suggest that novelty recognition and noradrenergic mechanisms are crucial in mediating neural plasticity induced by olfactory enrichment.
常用的环境富集实验范式包括增加社交互动、感官输入以及更新环境中的物品。然而,新奇性对富集效果的具体贡献尚不清楚。在这里,我们表明,每天重复暴露于单一的新奇气味剂而非丰富但稳定的嗅觉环境中,可改善小鼠嗅球的短期嗅觉记忆和神经发生。此外,这些积极作用是由去甲肾上腺素介导的,因为它们会被去甲肾上腺素能受体拮抗剂阻断。这些数据表明,新奇性识别和去甲肾上腺素能机制在介导嗅觉富集诱导的神经可塑性方面至关重要。