成人急性淋巴细胞白血病患者接受清髓性预处理后的无关供者脐血移植。
Unrelated cord blood transplantation after myeloablative conditioning in adults with ALL.
作者信息
Ooi J, Takahashi S, Tomonari A, Tsukada N, Konuma T, Kato S, Kasahara S, Sato A, Monma F, Nagamura F, Iseki T, Tojo A, Asano S
机构信息
Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
出版信息
Bone Marrow Transplant. 2009 Mar;43(6):455-9. doi: 10.1038/bmt.2008.347. Epub 2008 Oct 27.
We analyzed the disease-specific outcomes of adult ALL treated with cord blood transplantation (CBT) after myeloablative conditioning. Between October 2000 and November 2007, 27 adult patients with ALL were treated with unrelated CBT. All patients received four fractionated 12 Gy TBI and chemotherapy as myeloablative conditioning. The median age was 36 years, the median weight was 57 kg and the median number of nucleated cells was 2.47 x 10(7)/kg. All patients received a single and HLA-mismatched cord blood unit. The cumulative incidence of neutrophil recovery at day 30 and platelet recovery at day 200 was 92.6 and 92.3%, respectively. With a median follow-up of 47 months, the probability of EFS at 5 years was 57.2%. The 5-year cumulative incidence of TRM and relapse was 3.7 and 27.4%, respectively. These results suggest that unrelated CBT after myeloablative conditioning could be safely and effectively used for adult patients with ALL.
我们分析了清髓性预处理后接受脐血移植（CBT）的成人急性淋巴细胞白血病（ALL）患者的疾病特异性结局。在2000年10月至2007年11月期间，27例成人ALL患者接受了无关供者脐血移植治疗。所有患者均接受了4次分次剂量为12 Gy的全身照射（TBI）及化疗作为清髓性预处理。中位年龄为36岁，中位体重为57 kg，中位有核细胞数为2.47×10⁷/kg。所有患者均接受了单个且HLA配型不合的脐血单位。第30天中性粒细胞恢复和第200天血小板恢复的累积发生率分别为92.6%和92.3%。中位随访47个月，5年无事件生存率（EFS）概率为57.2%。5年移植相关死亡率（TRM）和复发的累积发生率分别为3.7%和27.4%。这些结果表明，清髓性预处理后无关供者脐血移植可安全有效地用于成人ALL患者。
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