用米吐尔和铬（VI）分光光度法测定某些抗阿米巴和驱虫药物

Spectrophotometric determination of some antiamoebic and anthelmintic drugs with metol and chromium(VI).

作者信息

Sastry C S, Aruna M, Mohana Rao A R

机构信息

Foods and Drugs Laboratories, School of Chemistry, Andhra University, Waltair 530003, India.

出版信息

Talanta. 1988 Jan;35(1):23-6. doi: 10.1016/0039-9140(88)80006-7.

DOI:10.1016/0039-9140(88)80006-7

PMID:18964459

Abstract

A sensitive spectrophotometric method is reported for the determination of tinidazole (TZ), metronidazole (MZ), benzoyl metronidazole (BMZ) or niclosamide (NS) either in pure form or in formulations. This method is based on reduction with zinc dust and hydrochloric acid followed by reaction with metol and potassium dichromate at pH 3.0 +/- 0.2 to give a coloured product having maximum absorbance at 720 nm (for TZ, MZ and BMZ) or 530 nm (for NS).

摘要

报道了一种灵敏的分光光度法，用于测定纯品或制剂中的替硝唑（TZ）、甲硝唑（MZ）、苯甲酰甲硝唑（BMZ）或氯硝柳胺（NS）。该方法基于用锌粉和盐酸还原，然后在pH 3.0±0.2条件下与米吐尔和重铬酸钾反应，生成在720nm处有最大吸光度的有色产物（用于TZ、MZ和BMZ）或在530nm处有最大吸光度的有色产物（用于NS）。