噻二嗪、牛磺罗定的研究-I. 采用¹H-和¹³C-核磁共振波谱法鉴定水溶液中存在的分子种类。
Studies of the thiadiazine, taurolidine-I. Identification of the molecular species present in aqueous solutions by (1)H- and (13)C-NMR spectroscopy.
作者信息
Hood H T, Smail G A, Skellern G G, Jindal D P, Browne M K, Pfirrmann R W
机构信息
Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, U.K.
出版信息
Talanta. 1994 Jan;41(1):107-13. doi: 10.1016/0039-9140(94)80175-4.
The equilibria in deuterium oxide solutions of the diamine, 4,4'-methylenebis(tetrahydro-1,2,4-thiadiazine-1,1-dioxide), were studied using highfield (1)H- and (13)C-NMR with the aid of solutions of tetrahydro-2H-1,2,4-thiadiazine-1,1-dioxide (taurultam), its two N-methyl detivatives and methylene glycol. Comparison of the (1)H-NMR spectrum of taurolidine with the one obtained from a mixture of taurultam and methylene glycol indicated that the same equilibria exists in both these solutions. It was concluded that taurolidine, taurultam and its 4-hydroxymethyl adduct and methylene glycol are the major components present. To facilitate the interpretation of the (13)C-spectra, (13)C-enriched methylene glycol was added to solutions of taurultam. The (13)C-studies confirmed the (1)H-NMR study.
借助四氢 - 2H - 1,2,4 - 噻二嗪 - 1,1 - 二氧化物（托鲁他姆）、其两种N - 甲基衍生物以及亚甲基二醇的溶液，利用高场（1）H - 和（13）C - NMR对二胺4,4'-亚甲基双（四氢 - 1,2,4 - 噻二嗪 - 1,1 - 二氧化物）在重水溶液中的平衡进行了研究。将托罗利定的（1）H - NMR谱与从托鲁他姆和亚甲基二醇的混合物获得的谱进行比较，结果表明这两种溶液中存在相同的平衡。得出的结论是，托罗利定、托鲁他姆及其4 - 羟甲基加合物和亚甲基二醇是主要存在的成分。为便于对（13）C - 谱进行解释，向托鲁他姆溶液中加入了富含（13）C的亚甲基二醇。（13）C研究证实了（1）H - NMR研究的结果。
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