Barbosa J, Barrón D, Beltrán J L, Butí S
Department of Analytical Chemistry, Universitat de Barcelona, Avda. Diagonal, 647, 08028 Barcelona, Spain.
Talanta. 1998 Mar;45(5):817-27. doi: 10.1016/s0039-9140(97)00167-7.
The dissociation constants of representative loop (furosemide), thiazide (chlorthiazide and trichlormethiazide) and potassium sparing (amiloride) diuretics in 10, 30, 40, 50 and 70% (w/w) acetonitrile-water mixtures at 298.15 K were determined, in accordance with IUPAC procedures. The variation in pK(a) values over the whole composition range can be explained by preferential solvation and the structural features in acetonitrile-water mixtures. Correlations between pK(a) values and various bulk and solvatochromic properties of the solvents were calculated. The linear solvation energy relationship (LSER) method was applied. The resulting equations allowed us to calculate pK(a) values for the diuretics studied in any acetonitrile-water mixture up to 70% (w/w) and should help to clarify the acid-base behaviour of diuretics in the widely-used acetonitrile-water mixed solvents.
按照国际纯粹与应用化学联合会（IUPAC）程序，测定了代表性的袢利尿剂（呋塞米）、噻嗪类利尿剂（氯噻嗪和三氯噻嗪）以及保钾利尿剂（阿米洛利）在298.15 K下于10%、30%、40%、50%和70%（w/w）乙腈 - 水混合物中的解离常数。整个组成范围内pK(a)值的变化可以通过优先溶剂化作用以及乙腈 - 水混合物中的结构特征来解释。计算了pK(a)值与溶剂的各种总体性质和溶剂化显色性质之间的相关性。应用了线性溶剂化能关系（LSER）方法。所得方程使我们能够计算在所研究的任何乙腈 - 水混合物（高达70%（w/w））中利尿剂的pK(a)值，并且应该有助于阐明利尿剂在广泛使用的乙腈 - 水混合溶剂中的酸碱行为。
Zotero 插件