Aarsland Dag, Rongve Arvid, Nore Sabine Piepenstock, Skogseth Ragnhild, Skulstad Siri, Ehrt Uwe, Hoprekstad Dagne, Ballard Clive
Department of Old Age Psychiatry, Stavanger University Hospital, Bergen, Norway.
Dement Geriatr Cogn Disord. 2008;26(5):445-52. doi: 10.1159/000165917. Epub 2008 Oct 31.
To find the proportion of dementia with Lewy bodies (DLB) in a referral cohort of patients with a first-time diagnosis of mild dementia.
The proportion of DLB among the dementia sufferers is not known and the clinical consensus criteria have low sensitivity. We employed the revised DLB criteria to study the proportion with DLB in a community sample of patients with mild dementia.
From March 2005 to March 2007, we included 196 patients from referrals to all geriatric medicine, old age psychiatry and neurology outpatient clinics in Rogaland and Hordaland counties in Western Norway. Standardized clinical instruments and diagnostic criteria were employed.
65% had Alzheimer dementia, 20% DLB (16% probable DLB), 5.6% vascular dementia, 5.6% Parkinson disease with dementia, 2.0% frontotemporal dementia and 1.5% alcoholic dementia. There were no significant differences in the proportion with DLB according to age bands and dementia severity groups. The revised criteria for a clinical diagnosis of DLB increased the proportion of probable DLB by 25% compared to the previous criteria.
DLB is common in patients with mild dementia, and is the second most common type of dementia. The introduction of new clinical criteria for DLB leads to an increase in the proportion diagnosed with probable DLB.
在首次诊断为轻度痴呆的转诊患者队列中，确定路易体痴呆（DLB）的比例。
痴呆患者中DLB的比例尚不清楚，且临床共识标准敏感性较低。我们采用修订后的DLB标准，研究轻度痴呆患者社区样本中DLB的比例。
2005年3月至2007年3月，我们纳入了挪威西部罗加兰郡和霍达兰郡所有老年医学、老年精神病学和神经科门诊转诊的196例患者。采用标准化临床工具和诊断标准。
65%为阿尔茨海默病性痴呆，20%为DLB（16%为很可能的DLB），5.6%为血管性痴呆，5.6%为帕金森病痴呆，2.0%为额颞叶痴呆，1.5%为酒精性痴呆。根据年龄组和痴呆严重程度组，DLB的比例无显著差异。与之前的标准相比，修订后的DLB临床诊断标准使很可能的DLB比例增加了25%。
DLB在轻度痴呆患者中很常见，是第二常见的痴呆类型。DLB新临床标准的引入导致很可能的DLB诊断比例增加。
