Guseĭnov T Iu
Anesteziol Reanimatol. 1991 May-Jun(3):14-7.
Using the data of arteriovenous differences, it has been for the first time demonstrated that patients with severe craniocerebral trauma (SCST) are characterized by glucose release by brain tissue combined with (p less than 0.05) pyruvate consumption. The above phenomenon is more often (p less than 0.05) associated with a more favourable course of SCST. A hypothesis is suggested of carbohydrate synthesis in hypoxia-affected brain tissues as a natural compensatory process. Conditions for gluconeogenesis are formed round macro- and microareas of brain damage with anaerobic metabolism bordering on tissues with aerobic metabolism. The process is responsible for energy and metabolic integration of disintegrated structures. Biological expediency of gluconeogenesis is glucose supply of anaerobic metabolism area with utilization of toxic metabolites, indirect energy maintenance of the affected area. Literature data supporting the hypothesis are presented.
利用动静脉差异数据，首次证明重度颅脑创伤（SCST）患者的特征是脑组织释放葡萄糖并伴有（p<0.05）丙酮酸消耗。上述现象更常（p<0.05）与SCST的更有利病程相关。提出了一个假设，即在缺氧影响的脑组织中进行碳水化合物合成是一种自然补偿过程。在脑损伤的宏观和微观区域周围形成糖异生的条件，厌氧代谢与有氧代谢组织相邻。该过程负责解体结构的能量和代谢整合。糖异生的生物学意义在于为厌氧代谢区域提供葡萄糖，利用有毒代谢产物，间接维持受影响区域的能量。文中列出了支持该假设的文献数据。
