Matos Renée I, Holcomb John B, Callahan Charles, Spinella Philip C
Department of Pediatrics, Lackland Air Force Base, TX 78236, USA.
Pediatrics. 2008 Nov;122(5):e959-66. doi: 10.1542/peds.2008-1244.
The objective of this study was to determine whether age <or=8 y is an independent predictor of mortality in noncoalition trauma patients at a US combat support hospital.
A retrospective chart review was conducted of 1132 noncoalition trauma patients who were admitted to a combat support hospital between December 2003 and December 2004. Data on age, severity of injury indices, and in-hospital mortality rates were analyzed. All variables that were associated with death on univariate analysis were analyzed by multivariate logistic regression to determine independent associations with mortality.
There were 38 young pediatric patients (aged <or=8 years) and 1094 older pediatric and adult patients (aged >8 years). Penetrating trauma accounted for 83% of all injuries. Young pediatric patients compared with older pediatric and adult patients had increased severity of injury indicated by decreased Glasgow Coma Scale score; increased incidence of hypotension, base deficit, and serum pH on admission; red blood cell transfusion amount; and increased injury severity scores on admission. Young pediatric patients compared with older pediatric and adult patients also had increased ICU lengths of stay (median 2 [interquartile range 0-5] vs median 0 [interquartile range 0-2] days) and in-hospital mortality rate (18% vs 4%), respectively. Multivariate logistic regression indicated that base deficit, injury severity score of >or=15, Glasgow Coma Scale score of <or=8, and age of <or=8 years were independently associated with mortality.
Young children who present to a combat support hospital have increased severity of injury compared with older children and adults. In a population with primarily penetrating injuries, after adjustment for severity of injury, young children may also have an independent increased risk for death compared with older children and adults. Providing forward-deployed medical staff with pediatric-specific equipment and training in the acute care of young children with severe traumatic injuries may improve outcomes in this population.
本研究的目的是确定年龄≤8岁是否是非联军创伤患者在美国一家战斗支援医院死亡的独立预测因素。
对2003年12月至2004年12月期间入住一家战斗支援医院的1132例非联军创伤患者进行回顾性病历审查。分析了年龄、损伤严重程度指数和院内死亡率的数据。对单因素分析中与死亡相关的所有变量进行多因素逻辑回归分析,以确定与死亡率的独立关联。
有38例年幼儿科患者(年龄≤8岁)和1094例年长儿科及成人患者(年龄>8岁)。穿透伤占所有损伤的83%。与年长儿科及成人患者相比,年幼儿科患者的损伤严重程度增加,表现为格拉斯哥昏迷量表评分降低;入院时低血压、碱缺失和血清pH值的发生率增加;红细胞输注量增加;入院时损伤严重程度评分增加。与年长儿科及成人患者相比,年幼儿科患者的重症监护病房住院时间也分别增加(中位数2天[四分位间距0 - 5天]对中位数0天[四分位间距0 - 2天])和院内死亡率增加(18%对4%)。多因素逻辑回归表明,碱缺失、损伤严重程度评分≥15、格拉斯哥昏迷量表评分≤8和年龄≤8岁与死亡率独立相关。
与年长儿童和成人相比,前往战斗支援医院就诊的幼儿损伤严重程度增加。在主要为穿透伤的人群中,在调整损伤严重程度后,幼儿与年长儿童和成人相比可能也有独立增加的死亡风险。向前方部署的医务人员提供针对儿童的设备,并对严重创伤幼儿进行急性护理培训,可能会改善该人群的治疗结果。