Spierer Lucas, Bourquin Nathalie M-P, Tardif Eric, Murray Micah M, Clarke Stephanie
Neuropsychology and Neurorehabilitation Service, Vaudois University Hospital Center, Lausanne, Switzerland.
Neuropsychologia. 2009 Jan;47(2):465-72. doi: 10.1016/j.neuropsychologia.2008.09.022. Epub 2008 Oct 15.
When two sounds are presented sequentially within a short delay ( approximately 10ms), the listener perceives a single auditory event, the location of which is dominated by the directional information conveyed by the leading sound (the precedence effect, PE). The PE is not always instantaneous, but has been shown to build-up across repetitions of lead-lag pairs. Here, we investigated the contributions of lateralization cue (interaural time and intensity differences; ITD and IID, respectively) and the side of lateralization of the leading sound on the spatio-temporal activity associated with the PE. We applied electrical neuroimaging analyses to compare auditory evoked potentials (AEPs) in response to physically identical click pairs presented early and late within a stimulus train and perceived as two segregated events or as one fused auditory event. Significant topographic AEP modulations associated with the PE were observed over the 70-117ms post-stimulus period, with one topography characterizing fused perceptions and another segregated perceptions. The specific pattern of effects varied as a function of lateralization cue and the lateralization of the leading sound. The PE for ITD stimuli built-up during the stimulus train irrespective of the lateralization of the leading sound. The PE for IID stimuli did not exhibit build-up over the course of the stimulus train, but instead was generally affected by the lateralization of the leading sound. Source estimations further suggested that bilateral temporal networks were engaged when perceptions were segregated, whereas fused perceptions resulted in decreased activity in left temporal and increased activity in right temporo-parietal cortices.
当两个声音在短延迟(约10毫秒)内相继呈现时,听者会感知到一个单一的听觉事件,其位置主要由领先声音传达的方向信息决定(优先效应,PE)。优先效应并非总是即时的,但已被证明会在领先-滞后对的重复过程中逐渐形成。在这里,我们研究了侧化线索(耳间时间和强度差异;分别为ITD和IID)以及领先声音的侧化对与优先效应相关的时空活动的贡献。我们应用电神经成像分析来比较对刺激序列中早期和晚期呈现的物理上相同的点击对的听觉诱发电位(AEP),这些点击对被感知为两个分离的事件或一个融合的听觉事件。在刺激后70-117毫秒期间观察到与优先效应相关的显著地形AEP调制,一种地形特征化融合感知,另一种特征化分离感知。具体的效应模式随侧化线索和领先声音的侧化而变化。ITD刺激的优先效应在刺激序列中逐渐形成,与领先声音的侧化无关。IID刺激的优先效应在刺激序列过程中未表现出逐渐形成,而是通常受领先声音侧化的影响。源估计进一步表明,当感知分离时,双侧颞叶网络被激活,而融合感知导致左颞叶活动减少,右颞顶叶皮质活动增加。