Liptak Julius M, Kamstock Debra A, Dernell William S, Monteith Gabrielle J, Rizzo Scott A, Withrow Stephen J
Animal Cancer Center and Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Vet Surg. 2008 Jul;37(5):488-96. doi: 10.1111/j.1532-950X.2008.00415.x.
To describe the clinical features and determine oncologic outcome and prognostic factors for dogs with primary tumors of the osseous chest wall.
Historical cohort.
Dogs (n=39) with spontaneous tumors involving the chest wall.
Medical records were reviewed for dogs with rib and/or sternal tumors treated by chest wall resection and reconstruction. Signalment, preoperative clinical features, reconstruction technique, and oncologic outcome (local tumor recurrence, metastasis, and survival time) were determined from medical records and by telephone contact with owners and referring veterinarians. Oncologic outcome and prognostic factors were determined using Kaplan-Meier survival analysis and Cox proportional hazards. Logistic regression was used to determine if increased serum alkaline phosphatase (ALP) concentration was associated with tumor type.
Of the 39 dogs with tumors arising from the chest wall, 25 had osteosarcoma, 12 had chondrosarcoma, and 2 dogs had hemangiosarcoma. Median survival time (MST) for dogs with rib osteosarcoma was 290 days. Increased activity of total ALP significantly decreased survival in dogs with osteosarcoma (210 days versus 675 days, P=.0035). MST for dogs with rib chondrosarcoma was not reached (mean 1301 days) and survival was significantly greater than all other types of rib tumors (P=.0321).
Rib tumors should be resected with wide margins to decrease the risk of incomplete excision, because local tumor recurrence has a significant impact on the survival time. The prognosis for dogs with rib chondrosarcoma is very good, but guarded for other types of tumors.
Osteosarcoma and chondrosarcoma are the most common primary tumors of the chest wall. Prognosis for dogs with primary rib chondrosarcoma is very good with surgery alone, but surgery and adjunctive chemotherapy is recommended for dogs with primary rib osteosarcoma and the prognosis remains guarded.
描述原发性胸壁骨肿瘤犬的临床特征,确定其肿瘤学转归及预后因素。
回顾性队列研究。
患有累及胸壁的自发性肿瘤的犬(n = 39)。
对接受胸壁切除及重建治疗的肋骨和/或胸骨肿瘤犬的病历进行回顾。从病历以及通过与犬主和转诊兽医电话联系来确定信号、术前临床特征、重建技术以及肿瘤学转归(局部肿瘤复发、转移和生存时间)。使用Kaplan-Meier生存分析和Cox比例风险模型确定肿瘤学转归及预后因素。采用逻辑回归分析确定血清碱性磷酸酶(ALP)浓度升高是否与肿瘤类型相关。
在39只胸壁肿瘤犬中,25只患有骨肉瘤,12只患有软骨肉瘤,2只患有血管肉瘤。肋骨骨肉瘤犬的中位生存时间(MST)为290天。总ALP活性升高显著降低了骨肉瘤犬的生存率(210天对675天,P = 0.0035)。肋骨软骨肉瘤犬的MST未达到(平均1301天),且生存率显著高于所有其他类型的肋骨肿瘤(P = 0.0321)。
肋骨肿瘤应进行广泛切除以降低切除不完全的风险,因为局部肿瘤复发对生存时间有显著影响。肋骨软骨肉瘤犬的预后非常好,但其他类型肿瘤的预后则不容乐观。
骨肉瘤和软骨肉瘤是胸壁最常见的原发性肿瘤。原发性肋骨软骨肉瘤犬仅通过手术预后非常好,但原发性肋骨骨肉瘤犬建议手术联合辅助化疗,其预后仍不容乐观。