Hoeppner Jacqueline, Neumeyer Martin, Wandschneider Roland, Herpertz Sabine C, Gierow Wolfgang, Haessler Frank, Buchmann Johannes
Department of Psychiatry and Psychotherapy, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany.
J Neural Transm (Vienna). 2008 Dec;115(12):1701-7. doi: 10.1007/s00702-008-0091-y. Epub 2008 Nov 6.
Using transcranial magnetic stimulation (TMS), disturbed facilitatory and inhibitory motor functions were recently found to correlate with motor hyperactivity in children with ADHD. Since hyperactivity seems to become reduced in ADHD during the transition to adulthood, a normalization of motor cortical excitability might be assumed. Therefore, we investigated the same inhibitory and facilitatory TMS paradigms in ADHD adults as we had previously examined in children. Motor cortical excitability was tested with TMS paired-pulse protocols in 21 ADHD adults and 21 age- and gender-matched healthy controls. In contrast to our results in ADHD children, no group-specific differences in amplitude changes of motor evoked potentials for inhibitory inter-stimulus intervals (ISI) (3, 100, 200 and 300 ms) or for facilitatory ISIs (13, 50 ms) could be detected. In ADHD adults, disturbed facilitatory and inhibitory motor circuits as found in ADHD children could not be shown, probably due to a development-dependent normalization of motor cortical excitability.
最近发现，使用经颅磁刺激（TMS）时，注意缺陷多动障碍（ADHD）儿童的促进性和抑制性运动功能紊乱与运动多动相关。由于多动症在向成年期过渡的过程中似乎会减轻，因此可以推测运动皮层兴奋性会恢复正常。因此，我们对ADHD成人进行了与之前对儿童进行的相同的抑制性和促进性TMS范式研究。采用TMS配对脉冲方案对21名ADHD成人和21名年龄及性别匹配的健康对照者进行运动皮层兴奋性测试。与我们在ADHD儿童中的结果相反，在抑制性刺激间隔（ISI）（3、100、200和300毫秒）或促进性ISI（13、50毫秒）的运动诱发电位幅度变化中，未检测到组间特异性差异。在ADHD成人中，未发现如ADHD儿童中那样的促进性和抑制性运动回路紊乱，这可能是由于运动皮层兴奋性的发育依赖性正常化所致。
