Seo Satoru, Doi Ryuichiro, Machimoto Takafumi, Kami Kazuhiro, Masui Toshihiko, Hatano Etsuro, Ogawa Kohei, Higashi Tatsuya, Uemoto Shinji
Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University, Kyoto, 606-8507, Japan.
J Hepatobiliary Pancreat Surg. 2008;15(6):634-9. doi: 10.1007/s00534-007-1339-x. Epub 2008 Nov 7.
BACKGROUND/PURPOSE: Pancreatic carcinoma has a poor prognosis, and early detection is essential to allow potentially curative resection. Despite the wide array of diagnostic tools available, the detection of small pancreatic tumors remains difficult. The aim of this study was to investigate the contribution of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to the diagnosis of early pancreatic cancer.
FDG-PET was performed in 56 patients with pancreatic cancer who underwent curative surgery. The standardized uptake value (SUV) for FDG was calculated in each patient and the relationships between the SUV and various clinicopathological factors were analyzed.
The tumors ranged from 0.8 to 6.5 cm in diameter. When the cutoff value for the SUV was set at 2.5, 51 of the 56 patients (91%) had a positive FDG-PET study. The SUV did not show a significant difference in relation to tumor differentiation or pTS and pT factors. There was also no correlation between the SUV and the maximum tumor diameter (r = 0.22; P = 0.1). Five tumors had an SUV below the cutoff value, and all of these lesions had intermediate or scirrhous stroma rather than medullary stroma.
These results indicate that FDG-PET is useful for the detection of small early pancreatic cancers.
背景/目的：胰腺癌预后较差，早期检测对于实现可能的根治性切除至关重要。尽管有多种可用的诊断工具，但小胰腺癌的检测仍然困难。本研究的目的是探讨18F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）在早期胰腺癌诊断中的作用。
对56例行根治性手术的胰腺癌患者进行FDG-PET检查。计算每位患者的FDG标准化摄取值（SUV），并分析SUV与各种临床病理因素之间的关系。
肿瘤直径范围为0.8至6.5厘米。当SUV的临界值设定为2.5时，56例患者中有51例（91%）FDG-PET检查呈阳性。SUV在肿瘤分化或pTS和pT因素方面未显示出显著差异。SUV与最大肿瘤直径之间也无相关性（r = 0.22；P = 0.1）。5个肿瘤的SUV低于临界值，所有这些病变均具有间质或硬癌间质而非髓质间质。
这些结果表明FDG-PET对小的早期胰腺癌检测有用。
