Pettus Liping H, Wurz Ryan P
Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, USA.
Curr Top Med Chem. 2008;8(16):1452-67. doi: 10.2174/156802608786264245.
The p38 mitogen-activated protein (MAP) kinase plays a central role in inflammation. It has been the subject of extensive efforts in both basic research and drug discovery for the treatment of inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, where aberrant cytokine signaling is the driver of the disease. This article reviews the patent and journal publication activities during 2006-2008 describing novel small molecule p38alpha inhibitors.
p38丝裂原活化蛋白（MAP）激酶在炎症中起核心作用。它一直是基础研究和药物研发的重点对象，用于治疗类风湿性关节炎、炎症性肠病和牛皮癣等炎症性疾病，这些疾病中异常的细胞因子信号传导是疾病的驱动因素。本文综述了2006年至2008年期间描述新型小分子p38α抑制剂的专利和期刊发表活动。
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