Sakamoto Seisuke, Ogura Yasuhiro, Shibata Toshiya, Haga Hironori, Ogawa Kohei, Oike Fumitaka, Ueda Mikiko, Egawa Hiroto, Takada Yasutsugu, Uemoto Shinji
Department of Surgery, Faculty of Medicine, Kyoto University, Kyoto, Japan.
Pediatr Transplant. 2009 Jun;13(4):507-11. doi: 10.1111/j.1399-3046.2008.01003.x. Epub 2008 Oct 7.
HVOO may lead to graft dysfunction in LDLT. Balloon angioplasty is the first treatment for HVOO. However, some cases with recurrent HVOO need multiple interventions and require stent placement. The authors describe a pediatric case with recurrent HVOO requiring multiple stent placements. Her symptoms related to HVOO finally disappeared after the third stenting. A year later, follow-up liver biopsy did not show any dramatic change in perivenular fibrosis. From a review of our pediatric cases with HVOO requiring stent placement, the majority of them lost the grafts, because the timing of stent placement was too late to prevent the progression of fibrosis. In conclusion, stent placement should be considered in select cases of HVOO. Serial liver biopsies evaluating the degree of fibrosis are essential in determining the timing of stent placement.
肝静脉流出道梗阻(HVOO)可能导致活体肝移植(LDLT)中的移植物功能障碍。球囊血管成形术是治疗HVOO的首选方法。然而,一些复发性HVOO病例需要多次干预并需要放置支架。作者描述了一例复发性HVOO的儿科病例,该病例需要多次放置支架。在第三次支架置入后,她与HVOO相关的症状最终消失。一年后,随访肝活检未显示肝周纤维化有任何显著变化。通过回顾我们需要放置支架的HVOO儿科病例,其中大多数失去了移植物,因为支架置入的时机太晚,无法阻止纤维化的进展。总之,对于某些HVOO病例应考虑放置支架。评估纤维化程度的系列肝活检对于确定支架置入的时机至关重要。