类固醇信号传导与温度依赖型性别决定——审视雌激素在龟类卵巢决定过程中早期作用的证据
Steroid signaling and temperature-dependent sex determination-Reviewing the evidence for early action of estrogen during ovarian determination in turtles.
作者信息
Ramsey Mary, Crews David
机构信息
Section of Integrative Biology, University of Texas, 2400 Speedway, Austin, TX 78712, United States.
出版信息
Semin Cell Dev Biol. 2009 May;20(3):283-92. doi: 10.1016/j.semcdb.2008.10.004. Epub 2008 Nov 1.
Abstract
The developmental processes underlying gonadal differentiation are conserved across vertebrates, but the triggers initiating these trajectories are extremely variable. The red-eared slider turtle (Trachemys scripta elegans) exhibits temperature-dependent sex determination (TSD), a system where incubation temperature during a temperature-sensitive period of development determines offspring sex. However, gonadal sex is sensitive to both temperature and hormones during this period-particularly estrogen. We present a model for temperature-based differences in aromatase expression as a critical step in ovarian determination. Localized estrogen production facilitates ovarian development while inhibiting male-specific gene expression. At male-producing temperatures aromatase is not upregulated, thereby allowing testis development.
摘要
性腺分化的发育过程在脊椎动物中是保守的，但启动这些发育轨迹的触发因素却极为多变。红耳龟（滑龟指名亚种）表现出温度依赖型性别决定（TSD），即发育的温度敏感期内的孵化温度决定后代性别的一种系统。然而，在此期间性腺性别对温度和激素都敏感，尤其是雌激素。我们提出了一个基于温度的芳香化酶表达差异模型，作为卵巢决定的关键步骤。局部雌激素的产生促进卵巢发育，同时抑制雄性特异性基因表达。在产生雄性的温度下，芳香化酶不被上调，从而允许睾丸发育。
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