3,6-双环内酯的合成：一类新型大环内酯类抗生素
Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics.
作者信息
Gai Yonghua, Tang Datong, Xu Guoyou, Chen Zhigang, Polemeropoulos Alexander, Wang Zhe, Or Yat Sun
机构信息
Enanta Pharmaceuticals, Inc., 500 Arsenal Street, Watertown, MA 02472, USA.
出版信息
Bioorg Med Chem Lett. 2008 Dec 15;18(24):6315-8. doi: 10.1016/j.bmcl.2008.10.109. Epub 2008 Oct 31.
PMID:18996692
Abstract
The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including resistant respiratory tract pathogens.
摘要
描述了从红霉素A肟合成3,6-双环内酯的方法。这类新型的桥连双环大环内酯类化合物对包括耐药呼吸道病原体在内的多种细菌表现出强大的体外和体内活性。
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