德国和欧洲儿童白血病的发病率、时间趋势及地区差异。
Incidence, time trends and regional variation of childhood leukaemia in Germany and Europe.
作者信息
Kaatsch Peter, Mergenthaler Andreas
机构信息
German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg-University Mainz, Obere Zahlbacher Strasse 69, 55131 Mainz, Germany.
出版信息
Radiat Prot Dosimetry. 2008;132(2):107-13. doi: 10.1093/rpd/ncn259. Epub 2008 Nov 7.
This paper presents data on the German and Europe-wide incidence, time trends and regional variations of childhood leukaemia. Data were provided by the German Childhood Cancer Registry (GCCR), a population-based cancer registry recording all cases of malignant diseases in children under 15 y of age residing in Germany and by the Automated Childhood Cancer Information System (ACCIS) co-ordinated at International Agency for Research on Cancer, Lyon, that combines and evaluates data from several European population-based cancer registries. The incidence of leukaemia (44.0 per million) has increased in Europe as well as in Germany in the last decades (0.6% annually on average). Germany shows no systematic aggregation of regions with low or high cancer incidence in terms of regional clustering. Incidence rates differ between European regions with the highest rates in Northern Europe (48.0 per million) and the lowest rates in Eastern Europe (39.1). Altogether, the results from ACCIS and the GCCR show good agreement.
本文介绍了德国及全欧洲儿童白血病的发病率、时间趋势和地区差异数据。数据由德国儿童癌症登记处（GCCR）提供，该登记处以人群为基础，记录居住在德国的15岁以下儿童所有恶性疾病病例；还由位于里昂的国际癌症研究机构协调的儿童癌症自动信息系统（ACCIS）提供，该系统整合并评估了来自几个欧洲人群为基础的癌症登记处的数据。在过去几十年里，欧洲以及德国的白血病发病率（每百万人口中44.0例）均有所上升（平均每年上升0.6%）。就地区聚集而言，德国并未出现癌症发病率低或高的地区的系统性聚集。北欧的发病率最高（每百万人口中48.0例），东欧的发病率最低（每百万人口中39.1例），欧洲不同地区的发病率有所不同。总体而言，ACCIS和GCCR的结果显示出良好的一致性。
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