Ota Masafumi, Tsujikawa Akitaka, Kita Mihori, Miyamoto Kazuaki, Sakamoto Atsushi, Yamaike Noritatsu, Kotera Yuriko, Yoshimura Nagahisa
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Retina. 2008 Nov-Dec;28(10):1502-8. doi: 10.1097/IAE.0b013e3181840b3c.
To study the correlation between final visual acuity and integrity of the foveal photoreceptor layer after resolution of macular edema (ME) associated with central retinal vein occlusion (CRVO).
We studied retrospectively 27 eyes of 27 patients with resolved ME associated with central retinal vein occlusion. On optical coherence tomography, integrity of the foveal photoreceptor layer was studied using the junctions between inner and outer segments of the photoreceptor (IS/OS) line as a hallmark.
At the final visit, foveal thickness was decreased to a physiologic level in all eyes. On optical coherence tomography, 14 eyes showed the IS/OS line in the fovea, whereas 13 eyes showed no IS/OS line. In concordance with resolution of the ME, visual acuity had improved significantly by the final visit. However, final visual acuity in eyes without an IS/OS line was significantly poorer than that in eyes with an IS/OS line (P < 0.0001). In addition, integrity of the foveal photoreceptor layer after resolution of the ME had a significant correlation with the initial retinal perfusion status (P = 0.0156) and with initial visual acuity (P = 0.0050).
After resolution of the ME associated with central retinal vein occlusion, visual acuity is closely associated with integrity of the foveal photoreceptor layer.
研究黄斑水肿（ME）消退后，黄斑中心凹光感受器层完整性与最终视力之间的相关性，该黄斑水肿与视网膜中央静脉阻塞（CRVO）相关。
我们回顾性研究了27例视网膜中央静脉阻塞相关黄斑水肿已消退患者的27只眼。在光学相干断层扫描中，以光感受器内、外节连接（IS/OS线）作为标志来研究黄斑中心凹光感受器层的完整性。
在最后一次随访时，所有患眼的黄斑厚度均降至生理水平。在光学相干断层扫描中，14只眼黄斑区可见IS/OS线，而13只眼未见IS/OS线。与黄斑水肿消退一致，最后一次随访时视力显著改善。然而，无IS/OS线患眼的最终视力明显低于有IS/OS线的患眼（P < 0.0001）。此外，黄斑水肿消退后黄斑中心凹光感受器层的完整性与初始视网膜灌注状态（P = 0.0156）和初始视力（P = 0.0050）显著相关。
视网膜中央静脉阻塞相关黄斑水肿消退后，视力与黄斑中心凹光感受器层的完整性密切相关。
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