Cohen R
Groupe de Pathologie Infectieuse Pédiatrique de la Société Française de Pédiatrie, Hôpital Intercommunal de Créteil et Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV), Créteil, France.
Arch Pediatr. 2008 Oct;15 Suppl 2:S53-8. doi: 10.1016/S0929-693X(08)74216-7.
The progress in the knowledge of antibiotic action mechanisms have led to determine phamacodynamic/pharmacokinetic (PK/PD) parameters predictive of antibiotic efficacy in bacterial infections. These parameters could vary according to the antibiotic compound, the bacterial specie implicated, the localization of the infection, the severity of the disease. The serum PK/PD parameters are predictive of efficacy in several infections (respiratory, skin, bone) and become a major criterion for selecting antibiotics in clinical practice. Moreover, these PK/PD parameters are the cornerstone of pre-clinical development of antibiotics, the determination of dosage and for the establishment of breakpoints for classifying strains in the sensitive or resistant area.
对抗生素作用机制认识的进展已促使人们确定预测细菌感染中抗生素疗效的药效学/药代动力学（PK/PD）参数。这些参数可能因抗生素化合物、相关细菌种类、感染部位、疾病严重程度而异。血清PK/PD参数可预测多种感染（呼吸道、皮肤、骨骼）的疗效，并成为临床实践中选择抗生素的主要标准。此外，这些PK/PD参数是抗生素临床前开发、剂量确定以及建立用于将菌株分类为敏感或耐药区域的断点的基石。
