[骨关节炎感染：临床研究]

[Osteoarticular infections: clinical studies].

作者信息

Grimprel E, Lorrot M, Haas H, Pinquier D, Parez N, Ferroni A, Cohen R

机构信息

Groupe de Pathologie Infectieuse Pédiatrique de la Société Française de Pédiatrie, Hôpital Armand Trousseau, 26 av Dr Arnold Netter 75012 Paris, Université Pierre et Marie Curie Paris VI, France.

出版信息

Arch Pediatr. 2008 Oct;15 Suppl 2:S68-73. doi: 10.1016/S0929-693X(08)74219-2.

DOI:10.1016/S0929-693X(08)74219-2

PMID:19000858

Abstract

Management of paediatric skeletal infections remains delicate in France due to the absence of general agreement or official recommendations from the French National Societies. However, practices have evolved since 40 years towards simplified and mostly ambulatory treatment modalities. The Paediatric Infectious Diseases Group of the French Society of Paediatrics (GPIP) has elaborated guidelines funded on the joint analysis of bacterial epidemiology, comparison of common antimicrobial spectra, pharmacokinetic and pharmacodynamic parameters and clinical studies. The aim of this article is to review the evolution of therapeutic concepts of treatment of bone and joint infections in paediatrics for 40 years with the aid of main published clinical studies.

摘要

在法国，由于缺乏法国各全国性学会的普遍共识或官方建议，小儿骨骼感染的管理仍然很棘手。然而，自40年来，治疗方式已朝着简化且大多为门诊治疗的方向发展。法国儿科学会的小儿传染病小组（GPIP）在对细菌流行病学进行联合分析、比较常见抗菌谱、药代动力学和药效学参数以及临床研究的基础上制定了指南。本文旨在借助主要已发表的临床研究，回顾40年来小儿骨与关节感染治疗理念的演变。