Montavont Alexandra, Kahane Philippe, Guenot Marc, Ryvlin Philippe
Department of Functional Neurology and Epileptology, Neurological Hospital, 59 Bd Pinel, 69003 Lyon, France.
Neurology. 2008 Nov 11;71(20):1579-85. doi: 10.1212/01.wnl.0000334934.59069.47.
Foreign language ictal speech automatism (FLISA) is a rare ictal sign that has been hitherto reported in five unilingual patients, all right handed men with right temporal lobe epilepsy (TLE), only one of whom has benefited from an intracerebral EEG investigation.
We report three unilingual French patients who consistently presented English spoken ictal speech automatisms and were investigated with intracerebral EEG recordings.
All three patients were right-handed men with nondominant TLE originating in the right amygdala. However, FLISA only occurred when the ictal EEG discharge spread to the ipsilateral temporal neocortex or frontal operculum. In addition, FLISA were emotionally salient, referring to the patient's parents or to the intensity of the ongoing seizure.
Our findings, together with previously published data, suggest that foreign language ictal speech automatisms are more likely to occur in men with nondominant amygdala onset seizures, an observation that might reflect the sexual dimorphism observed in the right amygdala during emotional processing.
外语发作性言语自动症（FLISA）是一种罕见的发作期体征，迄今为止仅在5名单语患者中被报道过，这些患者均为右利手男性，患有右侧颞叶癫痫（TLE），其中只有1人受益于脑内脑电图检查。
我们报告3名单语法语患者，他们持续出现说英语的发作性言语自动症，并接受了脑内脑电图记录检查。
所有3名患者均为右利手男性，非优势侧TLE起源于右侧杏仁核。然而，FLISA仅在发作期脑电图放电扩散至同侧颞叶新皮质或额盖时出现。此外，FLISA具有情感显著性，涉及患者的父母或当前发作的强度。
我们的研究结果与先前发表的数据表明，外语发作性言语自动症更可能发生在非优势侧杏仁核起病的男性患者中，这一观察结果可能反映了在情感加工过程中右侧杏仁核所观察到的性别差异。
