法尼醇作为白色念珠菌中的群体感应分子
[Farnesol as a quorum-sensing molecule in Candida albicans].
作者信息
Cho Tamaki, Aoyama Toshihiro, Toyoda Mika, Nakayama Hironobu, Chibana Hiroji, Kaminishi Hidenori, Calderone Richard A
机构信息
Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, Fukuoka, Japan.
出版信息
Nihon Ishinkin Gakkai Zasshi. 2008;49(4):281-6. doi: 10.3314/jjmm.49.281.
Farnesol is one of the quorum sensing molecules of Candida albicans. In this report, we discuss the effects of farnesol on: 1. growth of Candida albicans in vitro and in vivo; 2. the incorporation of biomolecules into the cell wall of Candida albicans; and 3. cytokine expression by the immune system. Our results indicate genes of Candida albicans expressed at an early stage of quorum-sensing. Half of these genes are known and two-thirds of known genes are up-regulated by two types of transcription factors.
法尼醇是白色念珠菌的群体感应分子之一。在本报告中，我们讨论了法尼醇对以下方面的影响：1. 白色念珠菌在体外和体内的生长；2. 生物分子掺入白色念珠菌细胞壁的情况；3. 免疫系统的细胞因子表达。我们的结果表明，白色念珠菌的基因在群体感应的早期阶段表达。这些基因中有一半是已知的，已知基因的三分之二被两种转录因子上调。
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