Peldschus Kersten, Hamdorf Mareike, Robert Philippe, Port Marc, Graessner Joachim, Adam Gerhard, Herborn Christoph U
Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Invest Radiol. 2008 Dec;43(12):837-42. doi: 10.1097/RLI.0b013e3181852158.
To evaluate the gadolinium-based contrast agent P846 and compare it with gadoterate meglumine (Gd-DOTA) for contrast-enhanced magnetic resonance angiography (MRA) in rabbits at 1.5 T and 3.0 T, respectively.
Five rabbits underwent contrast-enhanced MRA of the abdominal vasculature applying gadolinium doses of 0.025 mmoL/kg for P846 and 0.1 mmoL/kg for Gd-DOTA, respectively. All animals were examined on a 1.5-T and 3.0-T MR system. Image data were acquired during the first-pass arterial phase and repeatedly over 10 minutes. Contrast-to-noise-ratio (CNR) was determined in the aorta, the inferior vena cava, and the renal cortex. Image quality of arterial phase MR angiograms was consensually judged on a 5-point scale (5 = high).
Contrast-enhanced MRA was successful in all cases with both contrast agents. CNR values consistently proved statistically significantly higher for P846 compared with Gd-DOTA. CNR values in the aorta during the arterial phase were 46.0 +/- 3.7 (P846) and 28.0 +/- 3.2 (Gd-DOTA) at 1.5 T (P < 0.05), and correspondingly 89.3 +/- 12.7 (P846) and 64.1 +/- 15.0 (Gd-DOTA) at 3.0 T (P < 0.05). Image quality of arterial phase MR angiograms was rated with scores of 4.8 +/- 0.4 (P846) and 4.0 +/- 0.0 (Gd-DOTA) at 1.5 T (P = 0.06), and 5.0 +/- 0.0 (P846) and 4.8 +/- 0.4 (Gd-DOTA) at 3.0 T (P = 0.42), respectively.
The contrast agent P846 provides high contrast enhancement and image quality for contrast-enhanced MRA in rabbits at 1.5 T and 3.0 T with a 4-fold lower gadolinium dose compared with a standard extracellular contrast agent.
评估钆基造影剂P846，并分别在1.5 T和3.0 T场强下将其与钆喷酸葡胺（Gd-DOTA）用于兔的对比增强磁共振血管造影（MRA）进行比较。
5只兔分别接受腹部血管系统的对比增强MRA，P846的钆剂量为0.025 mmol/kg，Gd-DOTA的钆剂量为0.1 mmol/kg。所有动物均在1.5 T和3.0 T MR系统上进行检查。在首次通过动脉期及随后的10分钟内反复采集图像数据。在主动脉、下腔静脉和肾皮质测定对比噪声比（CNR）。动脉期MR血管造影的图像质量通过一致认可的5分制进行判断（5分 = 高）。
两种造影剂在所有病例中对比增强MRA均成功。与Gd-DOTA相比，P846的CNR值始终在统计学上显著更高。在1.5 T时，动脉期主动脉的CNR值分别为46.0±3.7（P846）和28.0±3.2（Gd-DOTA）（P<0.05），在3.0 T时相应为89.3±12.7（P846）和64.1±15.0（Gd-DOTA）（P<0.05）。在1.5 T时，动脉期MR血管造影的图像质量评分分别为4.8±0.4（P846）和4.0±0.0（Gd-DOTA）（P = 0.06），在3.0 T时分别为5.0±0.0（P846）和其4.8±0.4（Gd-DOTA）（P = 0.42）。
造影剂P846在1.5 T和3.0 T场强下为兔的对比增强MRA提供了高对比增强和图像质量，与标准细胞外造影剂相比，钆剂量降低了4倍。
