Patel H, Brunton V G
Edinburgh Cancer Research Centre, The University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, Scotland.
Cell Mol Life Sci. 2009 Jan;66(1):145-55. doi: 10.1007/s00018-008-8527-y.
Cell-cell adhesion is a critical property of all multi-cellular organisms and its correct regulation is critical during development, differentiation, tissue building and maintenance, and many immune responses. The multi-talin-like FERM domain containing protein, FrmA, is required during starvation-induced multi-cellular development of Dictyostelium cells. Loss of FrmA leads to increased cell-cell adhesion and results in impaired multi-cellular development, slug migration and fruiting bodies. Further, mixing experiments show that FrmA null cells are excluded from the apex of wild-type mounds, to which cells that normally form the organising centre known as the tip sort. These data suggest a critical role for FrmA in regulating cell-cell adhesion, multi-cellular development and, in particular, the formation of the organising centre known as the tip.
细胞间黏附是所有多细胞生物的一项关键特性，其正确调控在发育、分化、组织构建与维持以及许多免疫反应过程中至关重要。含有多talin样FERM结构域的蛋白质FrmA，在盘基网柄菌细胞饥饿诱导的多细胞发育过程中是必需的。FrmA的缺失会导致细胞间黏附增加，并导致多细胞发育、蛞蝓体迁移和子实体受损。此外，混合实验表明，FrmA缺失细胞被排除在野生型丘的顶端，而正常形成被称为尖端的组织中心的细胞会聚集到该顶端。这些数据表明FrmA在调节细胞间黏附、多细胞发育，特别是在被称为尖端的组织中心的形成中起关键作用。
