Song Laijun, Guo Fuyou, Zhang Wei, Sun Hongwei, Long Jiang, Wang Shukai, Bao Jianji
Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Henan, The People's Republic of China.
Neurol Sci. 2008 Dec;29(6):425-30. doi: 10.1007/s10072-008-1019-x. Epub 2008 Nov 11.
The purpose of this study was to investigate the clinical features and outcomes of brain abscess in patients in central China. Ninety consecutive patients with brain abscess were studied retrospectively. The rate of positive bacterial culture in the present series was 12%. The outcome of superficial abscesses was better than those of abscesses in deep-seated locations (p<0.01); multiple brain abscesses led to significantly poorer outcomes than unilocated abscesses (p<0.01). There was no significant difference between the paediatric group and the adult group (p>0.05). Differences in outcomes between intrathecal injection combined with systemic administration of antibiotics vs. only venous administration could not be found (p>0.05). The clinical effectiveness of tertiary-generation cephalosporin+vancomycin+metronidazole for bacterial brain abscess was 88%. Therefore, combined antibiotics in cases with no evidence of positive culture in brain abscess are strongly recommended.
本研究旨在调查中国中部地区脑脓肿患者的临床特征及预后。对90例连续的脑脓肿患者进行回顾性研究。本系列中细菌培养阳性率为12%。浅表脓肿的预后优于深部脓肿（p<0.01）；多发性脑脓肿的预后明显差于单发性脓肿（p<0.01）。儿童组和成人组之间无显著差异（p>0.05）。未发现鞘内注射联合全身抗生素给药与仅静脉给药在预后上的差异（p>0.05）。第三代头孢菌素+万古霉素+甲硝唑治疗细菌性脑脓肿的临床有效率为88%。因此，强烈推荐在脑脓肿细菌培养无阳性证据的病例中联合使用抗生素。
