氧合作用和血管生成在耐药性中的作用。
Role of oxygenation and vascularization in drug resistance.
出版信息
Cytotechnology. 1998 Sep;27(1-3):249-56. doi: 10.1023/A:1008033326059.
Oxygenation status and tumor vascularization seem to be important factors in determining therapeutic effectiveness and patient prognosis. An abundance of data on tumor oxygenation and vascularization is available and it clearly shows that most human solid tumors are heterogeneously oxygenated and vascularized. They contain hypoxic regions. Such regions and areas of reduced vascularization can affect the response to a variety of drugs. Direct measurements of pO(2) and the vascular density in various types of tumors have, upon correlation of the data to therapeutic outcome, shown that low pO(2) values and low vascular density are associated with a decreased response to therapy. Therefore, oxygenation status and the extent of tumor vascularization may well be important factors contributing to the difficulty of successful therapy in certain types of tumors.
氧合状态和肿瘤血管生成似乎是决定治疗效果和患者预后的重要因素。有大量关于肿瘤氧合和血管生成的数据，这些数据清楚地表明，大多数人体实体瘤的氧合和血管生成是不均匀的，它们含有缺氧区域。这些区域和血管生成减少的区域会影响对各种药物的反应。直接测量各种类型肿瘤的 pO(2) 和血管密度，并将数据与治疗结果相关联，结果表明，低 pO(2) 值和低血管密度与治疗反应降低有关。因此，氧合状态和肿瘤血管生成的程度可能是导致某些类型肿瘤治疗成功困难的重要因素。
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