Saul'skaia N B, Fofonova N V, Sudorgina P V
Zh Vyssh Nerv Deiat Im I P Pavlova. 2008 Sep-Oct;58(5):596-604.
By means of in vivo microdialysis combined with HPLC analysis it was shown that levels of extracellular citrulline (NO co-product) in the rat n. accumbens increased during expression of a conditioned fear response. Intraaccumbal infusions of a D2 receptor antagonist raclopride (10 microM) decreased the rise of extracellular citrulline produced by expression of the response but did not change behavioral characteristics of conditioned freezing. The raclopride infusions increased exploratory activity inhibited by acquisition of conditioned fear but did not affect the exploration of control rats. These data suggest that dopaminergic input to the n. accumbens and D2 dopamine receptors regulate activity of the accumbal nitrergic system during conditioned fear response and possibly control fear transfer to another behavioral situation.
通过体内微透析结合高效液相色谱分析表明，在大鼠伏隔核中，条件性恐惧反应表达期间细胞外瓜氨酸（一氧化氮的共同产物）水平升高。向伏隔核内注射D2受体拮抗剂雷氯必利（10微摩尔）可降低反应表达所产生的细胞外瓜氨酸的升高，但并未改变条件性僵住的行为特征。雷氯必利注射增加了因条件性恐惧习得而受到抑制的探索活动，但不影响对照大鼠的探索行为。这些数据表明，伏隔核的多巴胺能输入和D2多巴胺受体在条件性恐惧反应期间调节伏隔核氮能系统的活性，并可能控制恐惧向另一种行为情境的转移。
